Intervention | Comments |
---|---|
1. Withdrawal of offending medication (dapsone) | Drug discontinuation |
2. Supportive therapy | Â |
   • Volume replacement | Intravenous fluid replacement |
   • Nutritional support | Enteral or parenteral nutrition |
   • Antibiotics | Early antibiotic institution in case of concomitant sepsis |
   • Skin care | Preventing skin superinfection |
3. Specific therapy | Â |
   • Glucocorticoids | Recommended dose 1 mg/kg/day |
   • Thyroid hormone replacement | Associated late hypothyroidism |
   • Family counseling | Genetic factors involvement |