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Table 3 Solvent exposure and HL, B-NHL, and T-NHL (unconditional logistic regression analysis)

From: Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

 

Contr.

HL (n = 116)

B-NHL (n = 554)

T-NHL (n = 35)

 

N

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

CHLORINATED HYDROCARBONS

          

Chlorinated hydrocarbons in total [ppm*yrs.]

          

   0 ppm*yrs.

563

101

1.0

-

436

1.0

-

26

1.0

-

   >0, <= 4.4 ppm*yrs.

74

5

0.3

0.1–0.8

45

0.8

0.5–1.2

2

0.5

0.1–2.5

   >4.4, <= 47.3 ppm*yrs.

59

8

0.8

0.3–2.1

42

0.9

0.6–1.4

4

1.5

0.4–5.0

   >47.3 ppm*yrs.

14

1

0.5

0.1–4.6

27

2.4

1.2–4.7

1

1.3

0.1–11.4

Trend test*

  

p = 0.63 (neg.)

  

p = 0.02

  

p = 0.23

 

Trichloroethene [ppm*yrs.]

          

   0 ppm*yrs.

602

10.4

1.0

-

47+

1.0

-

27

1.0

-

   >0, <= 4.4 ppm*yrs.

55

6

0.4

0.2–1.1

32

0.7

0.5–1.2

2

0.7

0.2–3.3

   >4.4, <= 35 ppm*yrs.

44

3

0.4

0.1–1.4

27

0.8

0.5–1.3

2

1.1

0.2–5.1

   >35 ppm*yrs.

9

2

2.0

0.4–10.5

17

2.3

1.0–5.3

2

4.7

0.8–26.1

Trend test*

  

p = 0.97

  

p = 0.08

  

p = 0.09

 

Tetrachloroethene [ppm*yrs.]

          

   0 ppm*yrs.

679

111

1.0

-

521

1.0

-

30

1.0

-

   >0, <= 9.1 ppm*yrs.

16

3

1.7

0.4–6.9

12

0.9

0.4–2.0

1

1.7

0.2–14.4

   >9.1, <= 78.8 ppm*yrs.

13

1

0.7

0.1–6.3

12

1.0

0.5–2.3

1

1.5

0.2–12.5

   >78.8 ppm*yrs.

2

-

-

-

5

3.2

0.6–16.7

1

-

-

Trend test*

  

p = 0.74 (neg.)

  

p = 0.16

  

p = 0.01

 

CTET [ppm*yrs.]

          

   0 ppm*yrs.

696

113

1.0

-

530

1.0

-

33

1.0

-

   >0, <= 2.3 ppm*yrs.

8

1

0.8

0.1–8.5

12

1.8

0.7–4.6

-

-

-

   >2.3, <= 48.1 ppm*yrs.

5

1

3.7

0.4–33.6

7

1.5

0.5–4.8

-

-

-

   >48.1 ppm*yrs.

1

-

-

-

1

-

-

-

-

-

Trend test*

  

p = 0.86 (neg.)

  

p = 0.60

 

-

-

-

DCM [ppm*yrs.]

          

   0 ppm*yrs.

681

113

1.0

-

531

1.0

-

32

1.0

-

   >0, <= 26.3 ppm*yrs.

16

2

0.7

0.2–3.6

6

0.4

0.2–1.1

-

-

-

   >26.3, <= 175 ppm*yrs.

11

-

-

-

8

0.9

0.3–2.3

1

1.2

0.1–10.9

   >175 ppm*yrs.

2

-

-

-

5

2.7

0.5–14.5

-

-

-

Trend test*

  

p = 0.24 (neg.)

  

p = 0.29

  

p = 0.5

(neg.)

AROMATIC HYDROCARBONS

          

Benzene [ppm*yrs.]

          

   0 ppm*yrs.

590

101

1.0

-

459

1.0

-

26

1.0

-

   >0, <= 8.6 ppm*yrs.

60

9

1.0

0.4–2.3

41

0.9

0.6–1.4

3

1.2

0.3–4.4

   >8.6, <= 130 ppm*yrs.

48

5

0.9

0.3–2.5

39

1.0

0.6–1.5

3

1.7

0.5–6.1

   >130 ppm*yrs.

12

-

-

-

11

1.0

0.4–2.3

1

1.7

0.2–15.0

Trend test*

  

P = 0.22 (neg.)

   

P = 0.50

  

P = 0.83

Toluene [ppm*yrs.]

          

   0 ppm*yrs.

545

88

1.0

-

421

1.0

-

24

1.0

-

   >0, <= 3.5 ppm*yrs.

80

19

1.2

0.7–2.3

56

1.0

0.7–1.5

6

1.6

0.6–4.4

   >3.5, <= 207 ppm*yrs.

69

8

0.9

0.4–2.0

60

1.1

0.8–1.6

2

0.8

0.2–3.5

   >207 ppm*yrs.

16

-

-

 

13

0.9

0.4–2.0

1

1.3

0.2–1.6

Trend test*

  

P = 0.30 (neg.)

   

P = 0.43

  

P = 0.72

Xylene [ppm*yrs.]

          

   0 ppm*yrs.

552

88

1.0

-

432

1.0

-

24

1.0

-

   >0, <= 4.4 ppm*yrs.

80

20

1.4

0.7–2.6

48

0.8

0.5–1.2

6

1.7

0.6–4.7

   >4.4, <= 230 ppm*yrs.

63

8

0.8

0.3–2.0

59

1.2

0.8–1.7

2

0.8

0.2–3.6

   >230 ppm*yrs.

15

-

-

-

11

0.9

0.4–1.9

1

1.5

0.2–13.0

Trend test*

  

P = 0.31 (neg.)

   

P = 0.34

  

P = 0.63

Styrene [ppm*yrs.]

          

   0 ppm*yrs.

541

91

1.0

-

423

1.0

-

23

1.0

-

   >0, <= 1.5 ppm*yrs.

85

11

0.4

0.2–0.8

53

0.8

0.6–1.2

6

1.3

0.5–3.6

   >1.5, <= 67.1 ppm*yrs.

67

13

1.5

0.7–3.1

62

1.2

0.8–1.7

4

1.6

0.5–4.8

   >67.1 ppm*yrs.

17

-

-

-

12

0.8

0.4–1.8

-

-

-

Trend test*

  

P = 0.26 (neg.)

   

P = 0.18

  

P = 0.41 (neg.)

  1. Missing values were included as a separate category (not shown)
  2. a Odds Ratio (OR) adjusted for age, sex, region, smoking [packyears] and alcohol consumption [g per day]
  3. * To calculate tests for trend, the exposure scores were included as continuous variables in the logistic regression model; (neg.) means: p for trend for a negative association
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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673