Infectious diseases in healthcare workers – an analysis of the standardised data set of a German compensation board
© Nienhaus et al.; licensee BioMed Central Ltd. 2012
Received: 20 March 2012
Accepted: 3 May 2012
Published: 3 May 2012
Healthcare workers (HCW) are exposed to infectious agents. Disease surveillance is therefore needed in order to foster prevention.
The data of the compensation board that covers HCWs of non-governmental healthcare providers in Germany was analysed for a five-year period. For hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, the period analysed was extended to the last 15 years. The annual rate of occupational infectious diseases (OIDs) per 100,000 employees was calculated. For needlestick injuries (NSI) a rate per 1,000 employees was calculated.
Within the five years from 2005 to 2009 a total of 384 HCV infections were recognised as OIDs (1.5/100,000 employees). Active TB was the second most frequent cause of an OID. While the numbers of HBV and HCV infections decreased, the numbers for active TB did not follow a clear pattern. Needlestick injuries (NSIs) were reported especially often at hospitals (29.9/1,000 versus 7.4/1,000 employees for all other HCWs).
Although they are declining, HCV infections remain frequent in HCWs, as do NSIs. Whether the reinforcement of the recommendations for the use of safety devices in Germany will prevent NSIs and therefore HCV infections should be closely observed.
KeywordsHealthcare workers Infections Tuberculosis Needlestick injuries Blood-borne virus infections
It is well known that healthcare workers (HCWs) risk contracting infectious diseases . HCWs are at risk of infection with blood-borne pathogens during occupational exposure to blood and body fluids . The increased risk of tuberculosis (TB) infection for HCWs is well documented [3–5]. Emerging infectious diseases such as severe acute respiratory syndrome (SARS), H5/N1 avian influenza and H1/N1 swine influenza have shown the particular vulnerability of HCWs. SARS was identified as a new disease by WHO physician Dr. Carlo Urbani. He diagnosed it in a patient who died from the illness. Dr. Urbani subsequently died from SARS, too. SARS affected 8,096 individuals globally, 21% of whom were HCWs [6, 7]. SARS has been known to spread extensively among HCWs in various settings. In outbreaks in Hong Kong and Toronto, 62%  and 51%  of the infected patients were HCWs.
During the first outbreak of H5/N1 avian infections in Hong Kong in 1997, the prevalence of H5/N1 antibodies was five times higher in exposed HCWs than in HCWs without contact to avian influenza patients, i.e. 3.7% (8/217) versus 0.7% (2/309) . Even though H1/N1 swine influenza was well contained in Portugal, HCWs were at increased risk of contracting this infection . The increased risk of infection for HCWs is not always easy to detect. Working in healthcare was for a long time considered a safe place offering protection against tuberculosis. Only when the prevalence of tuberculosis declined in the general population did it become apparent that the rate of latent tuberculosis infection (LTBI) and active tuberculosis was high in those caring for tuberculosis patients . With the further decline of tuberculosis in high-income countries, interest in tuberculosis as an occupational disease dwindled. It was only with the emergence of HIV that interest in tuberculosis as a co-infection inspired research and fostered the prevention of infectious diseases in HCWs. In the aftermath of the HIV emergence, awareness of accidental blood contact and needlestick injuries rose, leading finally to the Needlestick Safety and Prevention Act in the US  and to the mandatory introduction of safety devices in Germany (TRBA 250 ) in order to prevent needlestick and sharps injuries as well as blood contact between patients and HCWs.
Surveillance data on occupational health risks is a cornerstone in occupational safety and health (OSH) management. Therefore new members of the enlarged European Union (EU) were encouraged to adopt the EU’s list of occupational diseases (ODs) and to build up their own monitoring system for surveying the burden of ODs in their countries . Reporting the data on claims of occupational infectious diseases (OIDs) filed by HCWs with the compensation board not only sheds light on important time trends in work-related health risks, but also stresses the importance of workplace prevention and hygiene. This type of surveillance system can be adopted by other countries with evolving social security systems in order to reduce the disease burden in HCWs .
Even though hygiene standards are high and access to vaccination is comprehensive in high-income countries like Germany, HCWs still remain vulnerable to infections at their workplaces. The aim of our study was to describe the number of infectious diseases in HCWs and to describe time trends using the standardised database of a compensation board.
The Berufsgenossenschaft for the healthcare (Gesundheitswesen) and welfare services (BGW) (Institution for Statutory Accident Insurance and Prevention) is the compensation board for all non-governmental healthcare and welfare providers in Germany. A total of 500,000 enterprises with about six million paid workers are covered by the BGW. The BGW’s database on compensation claims concerning the occupational disease number 3101, “infectious disease with human-to-human transmission”, was used for this analysis. The database allows a distinction to be made between the most frequent infectious diseases. Furthermore accidental blood contact reported to the compensation board can be identified. Contact with blood (or other body fluids) splashed onto the skin or the mucous membranes is coded as accidental blood contact (ABC). No information is available on whether the ABC occurred on intact or non-intact skin or on skin or mucous membranes. Injuries caused by used needles, scalpels or knives are coded as needlestick injuries (NSIs).
The reporting of suspected cases of ODs is compulsory for physicians and companies after first diagnosis. In the standardised data set, a further distinction is made between ODs that are mandatorily reportable and those that are not. Reporting ABC is not mandatory. ABC in the form of splashes is documented as an OID. It is reported to the compensation board because the cost of post-exposure prevention is covered by the board. NSIs are documented as working accidents. They must only be reported if they cause sick leave of more than three days, which they do not normally. However, they are reported in order to obtain compensation for the cost of post-exposure prevention independent of any sick leave.
The distinction between infectious diseases was introduced at different times and is available only for the most important infectious diseases. Claims of OIDs were analysed for 2009. Time trends over five years were analysed for claims concerning tuberculosis (TB), latent tuberculosis infection (LTBI), scabies, methicillin-resistant Staphylococcus aureus (MRSA), human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), ABC and NSIs. As the data set allows a distinction to be made between hepatitis B virus (HBV) and hepatitis C virus (HCV) starting in 1995, time trends are given for the 15 years between 1995 and 2009 for these infections. LTBI was considered present if the interferon-γ release assay (IGRA) was positive and active TB was excluded by X-ray.
We calculated rates of OIDs per 100,000 employees and of NSIs and ABC per 1,000 employees. In order to reduce variation by chance, these rates were calculated as an average for the last five years.
The prevalence of OIDs, ABCs and NSI were analysed for selected working areas in healthcare. These working areas correspond to clustered occupational groups, including settings with comparable risks of accidents and diseases, which are used in combination with compensation money to calculate insurance premiums. For the analyses, four working areas were selected: 1.) hospitals and other clinical facilities (referred to as hospitals in the following), 2.) medical surgeries with all kind of specialisations (referred to as surgeries), 3.) nursing homes, hospices, and other long-term care facilities (referred to as nursing homes), 4.) outpatient medical and social care, emergency medical services (referred to as outpatient care). The remaining occupational groups – including veterinary practices, hairdressing, administration, day care, social welfare services and facilities for the handicapped – were pooled (referred to as others in the following). Five-year trends for the most frequent infectious diseases were analysed separately for these working areas. Regulations for using safety devices were bolstered in Germany in 2008. Therefore claims of NSIs and ABC were analysed depending on working areas for 2008 and 2009 in order to see whether the new regulations had decreased the number of NSIs or ABC in the different working areas. Costs for NSIs and ABC were extracted from the data set for a five-year period.
Number of suspected cases of occupational infectious diseases (OD no. 3101) for 2009 separated by notification requirement, data from BGW, German
Occupational infectious diseases (OD no. 3101)
N (row %)
N (row %)
Hepatitis virus infection (total)
Number of needlestick injuries and blood contact cases and annual mean rates per 1,000 employees by different risk groups in 2008 and 2009; data from BGW, Germany
Number of suspected (S) and recognised (R) cases of selected occupational infectious diseases by year of notification and annual rates of recognised cases per 100,000 employees; 2005−2009; data from BGW, Germany
Occupational infectious diseases
Annual rate of recognised cases+
Annual mean rates of recognised cases of occupational infectious diseases per 100,000 employees by different risk groups; 2005−2009; data from BGW, Germany
Occupational infectious disease
To our knowledge this study is the first attempt to describe in detail the number of infectious diseases in German HCWs using data of a compensation board. This analysis has revealed different time trends. The most significant trend is that the number of HBV and HCV infections recognised as OIDs has declined during the last 15 years, with HCV infections now more often being the cause of an OID than HBV infections. However, the cases of NSIs and ABCs (splashes) filled to the board increased steadily over the last five years.
So far, only a few analyses of compensation claims by HCWs have been published. A US analysis of NSI claims by HCWs eligible to file a state fund workers’ compensation claim in Washington State established that the incidence of NSI claims per 1,000 HCWs employed in hospitals was 15.9, in dental offices 10.5, in physicians’ offices 8.7 and in skilled nursing facilities 8.1 . In our data set, rates of NSIs per 1,000 employees were twice as high in hospitals (29.8) but half as high in nursing homes (3.7). However, not all facilities clustered in this working area can be classified as skilled nursing facilities and therefore our denominator in this group is inflated. In addition comparison of the two studies is not possible as different time periods were analysed (1996 to 2000 in the US study  and 2008 to 2009 in our study).
A second study based on compensation claims for OIDs was a case series of HCWs with confirmed MRSA infections . The authors used the same data set as we did to identify MRSA-related OID claims and performed an in-depth analysis of the individual files. In total 17 MRSA-related OIDs were identified in HCWs. The analysis of compensation claims by veterinarians in Germany found an increased risk of animal-related accidents and infections . The literature that has been published to date on claims filed by HCWs makes it clear that, whatever the shortcomings of this data, analysing compensation claims by HCWs can be helpful in tackling the occupational risks faced by HCWs.
In Germany, a low-incidence country for TB, the rate of active TB as an OID in HCWs was even lower than expected (5.5/100,000 in the general population and 1.5/100,000 in HCWs). Under-representation of HCWs among patients with active TB was also observed in the Hamburg fingerprint study . However, it should be noted that HCWs do not share most other risks for active TB, for example homelessness, intravenous drug abuse or alcoholism. Therefore the risk of progression to active TB seems to be lower in HCWs than in close contacts of the general population . LTBI was reported and recognised as an OID more often in 2008 and 2009 than in the years before. This reflects the improvement in diagnosing LTBI, which was brought about by introducing the interferon-γ release assay into routine screening of HCWs [20–24]. High progression rates in close contacts to TB patients observed in Germany further fostered the awareness of LTBI as a risk for HCWs [25, 26].
HBV infection can be prevented by vaccination. In Germany, vaccinations are offered to every HCW at risk of infection during a mandatory physical examination at the workplace following the Biological Agents Ordinance. Therefore, HBV vaccination coverage in German HCWs is high and the decreasing number of HBV-related OIDs is well explained. However, the number of HCV-related OIDs decreased as well. A similar trend was observed in France . As no vaccine is available for HCV, this might indicate improvements in the realm of occupational hygiene.
Experiences in the US and Francedemonstrate that NSIs can be prevented [13, 27]. In Germany the number of NSIs reported is still high, and it should be assumed that the real incidence of NSIs in HCWs is even higher due to under-reporting. In 2008 regulations on the use of safety devices became more rigorous in Germany. Following these regulatory changes, safety devices were more often used in German healthcare. In the absence of a systematic evaluation, the experience in Hamburg might be reported. After informing hospitals about the new regulations and advising these hospitals on safety devices, all hospitals in Hamburg introduced them to varying degrees and subsequently reported a decrease in NSIs . However, the number of NSI related claims to the compensation board so far did not decrease. Annual costs for ABC and NSIs amounted to about 4 million euros. However, it should be noted that the real cost is underestimated because the compensation cost for blood-borne infections is not included in this estimate and under-reporting of ABC and NSIs is very likely. A more in-depth analysis of the cost of OIDs might be helpful in order to demonstrate the economic burden of OIDs in healthcare.
This analysis was based on the routine data of one compensation board, which covers about two thirds of all HCWs in Germany. The completeness of the data depends on the willingness of physicians and HCWs to report incidents. It might be safe to assume that – especially with less severe infectious diseases – there is considerable under-reporting because little monetary interest is involved. The annual incidence of NSI in HCWs of a university hospital was 31.4% . Compared to the annual rate of 29.9 NSI per 1,000 employees in hospitals (Table 2), it follows that about 10% of the NSI are reported to the compensation board. The advisors who are responsible for documenting claims are trained for their task. However, the quality of data entries is controlled in a rather superficial way. Therefore misclassification is likely. These limitations considered, the standard data set on occupational diseases of the Berufsgenossenschaft (compensation board) allow for a cautious estimate of the risk of infectious diseases in HCWs in Germany and enable meaningful time trends to be observed.
As the risk for OID remains high (e.g. 15.3/100,000 hospital employees, Table 4), awareness for the infection risk and knowledge about infection prevention should be improved [30, 31]. Communicating the safety and effectiveness of vaccination will be an important issue in this endeavour [32–34] as well as improvements in protective equipment likes gloves or safety devices [35, 36].
Even though Germany is a low-incidence country, TB still poses a threat for HCWs and screening for TB should therefore be maintained. Even though they are declining, HBV and HBV infections are still frequent and trends should be watched closely. Trends in NSIs should be observed closely in the following years in order to evaluate the effect of new regulations on the use of safety devices.
- Sepkowitz KA, Eisenberg L: Occupational deaths among healthcare workers. Emerg Infect Dis 2005,11(7):1003–1008. 10.3201/eid1107.401038PubMed CentralView ArticlePubMedGoogle Scholar
- Tarantola A, Abiteboul D, Rachline A: Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases. Amer J Inf Contr 2006,34(6):367–375. 10.1016/j.ajic.2004.11.011View ArticleGoogle Scholar
- Baussano I, Nunn P, Williams B, Pivetta E, Bugiani M, Scano F: Tuberculosis among health care workers. Emerg Infect Dis 2011,17(3):488–494.PubMed CentralView ArticlePubMedGoogle Scholar
- Seidler A, Nienhaus A, Diel R: Review of epidemiological studies on the occupational risk of tuberculosis in low-incidence areas. Respiration 2005,72(4):431–446. 10.1159/000086261View ArticlePubMedGoogle Scholar
- Diel R, Seidler A, Nienhaus A, Rusch-Gerdes S, Niemann S: Occupational risk of tuberculosis transmission in a low incidence area. Respir Res 2005,6(1):35–45. 10.1186/1465-9921-6-35PubMed CentralView ArticlePubMedGoogle Scholar
- Ho PL, Becker M, Chan-Yeung MM: Emerging occupational lung infections. Int J Tuberc Lung Dis 2005,11(7):710–721.Google Scholar
- Poon LL, Guan Y, Nicholls JM, Yuen KY, Peiris JS: The aetiology, origins and diagnosis of severe acute respiratory syndrome. Lancet Infect Dis 2004,4(11):663–671. 10.1016/S1473-3099(04)01172-7View ArticlePubMedGoogle Scholar
- Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GMA, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S, Sung JJ: Major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003,348(20):1986–1994. 10.1056/NEJMoa030685View ArticlePubMedGoogle Scholar
- Booth CM, Matukas LM, Tomlinson GA, Rachlis AR, Rose DB, Dwosh HA, Walmsley SL, Mazzulli T, Avendano M, Derkach P, Ephtimios IE, Kitai I, Mederski BD, Shadowitz SB, Gold WL, Hawryluck LA, Rea E, Chenkin JS, Cescon DW, Poutanen SM, Detsky AS: Clinical features and short term outcomes of 144 patients with SARS in the Greater Toronto Area. JAMA 2003,289(21):2801–2809. 10.1001/jama.289.21.JOC30885View ArticlePubMedGoogle Scholar
- Buxton Bridges C, Katz JM, Seto WH, Chan PK, Tsang D, Ho W, Mak KH, Lim W, Tam JS, Clarke M, Williams SG, Mounts AW, Bresee JS, Conn LA, Rowe T, Hu-Primmer J, Anernathy RA, Lu X, Cox NJ, Fukuda K: Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J Infect Dis 2000, 181: 344–348. 10.1086/315213View ArticlePubMedGoogle Scholar
- Costa JT, Silva R, Tavares M, Nienhaus A: High effectiveness of pandemic influence A (H1/N1) vaccination in healthcare workers from a Portuguese hospital. Int Arch Occup Environ Health 2011,:PMID: 22045387. epub ahead of printGoogle Scholar
- Sepkowitz KA: Tuberculosis and the healthcare worker. A historical perspective. Ann Intern Med 1994, 120: 71–79.PubMedGoogle Scholar
- Phillips EK, Conaway MR, Jagger JC: Percutaneous injuries before and after the Needlestick Safety and Prevention Act. N Engl J Med 2012,336(7):670–671.View ArticleGoogle Scholar
- TRBA 250 - Technical norm biological working material 250 (Technische Regel Biologische Arbeitsstoffe) last revision. 2008. [http://www.baua.de/nn_15116/de/Themen-von-A-Z/Biologische-Arbeitsstoffe/TRBA/pdf/TRBA-250.pdf(inGerman)]
- European Commission; Commission Recommendation of 19th September 2003 concerning the European schedule of occupational diseases. 2003/670/EC. [http://eur-lex.europa.eu/JOHtml.do?uri=OJ:L2003:SOM:EN:HTML]
- von Hirschberg KR, Kähler B, Nienhaus A: Social care and changes in occupational accidents and diseases – the situation in Eastern Europe in general and for skin diseases in particular. J Occup Med Toxicol 2009, 4: 28. 10.1186/1745-6673-4-28PubMed CentralView ArticlePubMedGoogle Scholar
- Shah SM, Bonauto D, Silverstein B, Foley M: Workers’ compensation claims for needlestick injuries among healthcare workers in Washington State, 1996–2000. Infect Control Hosp Epidemiol 2005,26(9):775–781. 10.1086/502616View ArticlePubMedGoogle Scholar
- Haamann F, Dulon M, Nienhaus A: MRSA as an occupational disease: a case series. Int Arch Occup Environ Health 2011,84(3):259–266. 10.1007/s00420-010-0610-7PubMed CentralView ArticlePubMedGoogle Scholar
- Nienhaus A, Skudlik C, Seidler A: Work-related accidents and occupational diseases in veterinarians and their staff. Int Arch Occup Environ Health 2005, 78: 230–238. 10.1007/s00420-004-0583-5View ArticlePubMedGoogle Scholar
- Nienhaus A, Schablon A, Siano B, le Bacle C, Diel R: Evaluation of the interferon-gamma release assay in healthcare workers. Int Arch Occup Environ Health 2008, 81: 295–300.View ArticlePubMedGoogle Scholar
- Ringshausen FC, Schlosser S, Nienhaus A, Schablon A, Schultze-Werninghaus G, Rohde G: In-hospital contact investigation among health care workers after exposure to smear-negative tuberculosis. J Occup Med Toxicol 2009,4(1):11. 10.1186/1745-6673-4-11PubMed CentralView ArticlePubMedGoogle Scholar
- Schablon A, Harling M, Diel R, Nienhaus A: Risk of latent TB infection in individuals employed in the healthcare sector in Germany: a multicentre prevalence study. BMC Infect Dis 2010, 10: 107. 10.1186/1471-2334-10-107PubMed CentralView ArticlePubMedGoogle Scholar
- Tripodi D, Brunet-Court B, Nael V, Audrain M, Chailleux E, Germaud P, Naudin F, Muller JY, Bourrut-Lacouture M, Durand-Perdriel MH, Gordeeff C, Guillaumin G, Houdebine M, Raffi F, Boutoille D, Biron C, Potel G, Roedlich C, Geraut C, Schablon A, Nienhaus A: Evaluation of the tuberculin skin test and the interferon-gamma release assay for TB screening in French healthcare workers. J Occup Med Toxicol 2009, 4: 30. 10.1186/1745-6673-4-30PubMed CentralView ArticlePubMedGoogle Scholar
- Torres Costa J, Sá R, Cardoso MJ, Silva R, Ferreira J, Ribeiro C, Miranda M, Plácido JL, Nienhaus A: Tuberculosis screening in Portuguese healthcare workers using the tuberculin skin test and the interferon-gamma release assay. Eur Respir J 2009, 34: 1423–1428. 10.1183/09031936.00053809View ArticlePubMedGoogle Scholar
- Diel R, Loddenkemper R, Meywald-Walter K, Niemann S, Nienhaus A: Predictive value of a whole blood IFN-c assay for the development of active TB disease. Am J Respir Crit Care Med 2008, 177: 1164–1170. 10.1164/rccm.200711-1613OCView ArticlePubMedGoogle Scholar
- Diel R, Loddenkemper R, Niemann S: Meywald-Walter, Nienhaus A: Negative and positive predictive value of a whole-blood Interferon-γ Release Assay for developing active tuberculosis - An Update. Am J Respir Crit Care Med 2011, 183: 88–95. 10.1164/rccm.201006-0974OCView ArticlePubMedGoogle Scholar
- Tosini W, Ciotti C, Goyer F, Lolom I, L’Hériteau F, Abiteboul D, Pellissier G, Bouvet E: Needlestick injury rates according to different types of safety-engineered devices: results of a French multicenter study. Infect Control Hosp Epidemiol 2010,31(4):402–407. 10.1086/651301View ArticlePubMedGoogle Scholar
- Gerdes S, Haamann F, Dittmann A, Swida U, Nienhaus A: Evaluation of the introduction of safety devices in the hospitals of Hamburg, in: Nienhaus A: Risk profiles (Gefährdungsprofile) – accidents and work related diseases in the healthcare and welfare sectors. Ecomed, Landsberg; 2010. (available in German only)Google Scholar
- Wicker S, Jung J, Allwinn R, Gottschalk R, Rabenau HF: Prevelence and prevention of needlestick injuries among health care workers in a German university hospital. Int Arch Occup Environ Health. 2008,81(3):347–354.View ArticlePubMedGoogle Scholar
- Deuffic-Burban S, Dalarocque-Astagneau E, Abitelboul D, Bouvet E, Yazdanpanah Y: Blood-borne viruses in a health care workers: prevention and management. J Clin Virol 2011,52(1):4–10. 10.1016/j.jcv.2011.05.016View ArticlePubMedGoogle Scholar
- Hofmann F, Ferracin C, Marsh G, Dumas R: Influenza vaccination of healthcare workers: a literature review of attitudes and beliefs. Infection 2006,34(3):142–147. 10.1007/s15010-006-5109-5View ArticlePubMedGoogle Scholar
- Johnson JG, Talbot TR: New approaches for influenza vaccination of healthcare workers. Curr Opin Infect Dis 2011,24(4):363–369. 10.1097/QCO.0b013e328347b0e7View ArticlePubMedGoogle Scholar
- McLennan S, Wicker S: Reflections on the influenza vaccination of healthcare workers. Vaccine 2012,28(51):8061–8064.View ArticleGoogle Scholar
- Wicker S, Rabenbau HF, Doerr HW, Allwinn R: Influenza vaccination compliance among health care workers in a German university hospital. Infection 2009,37(3):197–202. 10.1007/s15010-008-8200-2View ArticlePubMedGoogle Scholar
- Wittmann A, Kralj N, Köver J, Gasthaus K, Lerch H, Hofmann F: Comparison of 4 different types of surgical gloves used for preventing blood contact. Infect Control Hosp Epidemiol 2010,31(5):498–502. 10.1086/652158View ArticlePubMedGoogle Scholar
- Wittmann A, Kralj N, Köver J, Gasthaus K, Hofmann F: Study of blood contact in simulated surgical needlestick injuries with single or double latex gloving. Infect Control Hosp Epidemiol 2009,30(1):53–56. 10.1086/593124View ArticlePubMedGoogle Scholar
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