Table 2 Characteristics of included studies
From: The effect of silver nanoparticles on learning and memory in rodents: "a systematic review"
| Â | author | animal | sex | age | AgNPs size (nm) | Dose/ days | administration | test | result |
|---|---|---|---|---|---|---|---|---|---|
1 | B. Bouta 2016 [16] | rat | male | adult | 10 ± 4 | 0.2 mg/kg 14 days | gavage | NORT | p > 0.05 |
2 | Sh. Khezri 2022 [17] | rat | male | adult | 10 | 50 ppm 100 ppm 200 ppm 400 ppm 21 days | IP | NORT | p > 0.05 p < 0.05 p < 0.001 p < 0.001 |
MWM | Significant in sizes > 50 ppm For both learning and memory values | ||||||||
Y-maze | In treated groups with sizes > 50 ppm: p < 0.001 | ||||||||
3 | M. Ghaleb 2021 [18] | mice | male | adult | 19.5 ± 5 | 40 mg/kg 35 days | IP | T-maze | p < 0.001 |
MWM | For both learning and memory values: p < 0.001 | ||||||||
PAL | p < 0.001 | ||||||||
4 | K.Dziendzikowska 2021 [19] | rat | male | adult | 20 ± 5 | 0.5 mg/kg 28 days | orally | PAL | p < 0.05 |
5 | M. Wesierskaa 2018 [19] | rat | male | adult | 20 ± 5 | *1 mg/kg **30 mg/kg 28 days | orally | Carousel Maze | *p < 0.001 **p < 0.003 |
6 | L. Davenport 2015 [20] | mice | male | adult | 25 | 50 mg/kg 7 days | IP | NORT | p > 0.05 |
MWM | Learning: p > 0.05 Memory: p < 0.05 | ||||||||
7 | L. Hritcu 2011 [21] | rat | male | adult | 29 and 23 | 5 µg/kg 10 µg/kg 7 days | IP | Y-Maze | In both treated groups: p < 0.0001 |
Radial arm maze | In both treated groups: p < 0.01 | ||||||||
8 | I. Zinicovscaia 2021 [22] | mice | male | adult | 34 ± 1.4 | 13 mg/ml 4 month 2 month | orally | MWM | Learning: No difference Memory: No difference |
9 | A. Antsiferova 2018 [23] | mice | male | adult | 34 ± 2 and 31 ± 10 | 2 µg/mL 30 days 60 days 120 days 180 days | orally | contextual fear conditioning | No difference in learning in all groups except 180: p < 0.01 No difference in memory in all groups except 180: p < 0.05 |
10 | A. Antsiferova 2021 [24] | mice | male | adult | 34 ± 5 | 50 µg/mL 30 days 60 days 120 days 180 days | orally | contextual fear conditioning | Learning in all treated groups: No difference Memory: No difference No difference No difference p < 0.05 |
11 | P. Liu 2012 [25] | mice | male | adult | 36.3 ± 1.2 | 10 mg/kg 25 mg/kg 50 mg/kg 7 days | IP | MWM | In all groups: Learning: No difference Memory: No difference |
12 | Y. Liu 2012 [26] | rat | male | adult | 32.68 to 38.21 | 3 mg/kg 30 mg/kg 12 days | Intranasal | MWM | In both treated groups: Learning: p < 0.01 memory: p < 0.05 |
13 | Kh. Greish 2019 [15] | mice | male | adult | 1 to 100 Average:35 | mg/kg 2 μg per animal 1 dose 2 doses/ 1 w 3 doses/3 w | IV | MWM | Learning in all treated groups: p < 0.0001 memory: p < 0.05 p < 0.005 p < 0.001 |
14 | J. Wu 2015 [27] | rat | male | Offspring PND35 | 20 to 50 Average:35 | 0.427 mg Ag per g rat During pregnancy | IP | MWM | Learning: p < 0.05 memory: p < 0.05 |
15 | S. Ghaderi 2015 [28] | mice | Male Female | Offspring PND45-49 | 5 to 70 Average: 32 ± 6.6 | * 0.2 mg/kg **2 mg/kg During Pregnancy (once every 3 days) | Subcutaneous | MWM | Learning: * p > 0.05 **p < 0.01 memory: * p < 0.05 **p < 0.01 |
PAL | p > 0.05 |