The Dapsone Hypersensitivity Syndrome revisited: a potentially fatal multisystem disorder with prominent hepatopulmonary manifestations

Table 1 Adverse reactions to Dapsone

System	Manifestations	Mechanisms
Systemic
• *DHS	Dermatitis, hepatitis	Idisosyncratic
• **DRESS syndrome	Dermatitis, eosinophilia	Idiosyncratic
• Nonspecific	Nausea, headache, dizzy Weakness/fatigue	Predictable
Hematological	Hemolytic anemia	Predictable (G6PDD)
	Methemoglobinemia	Predictable
Neurological	Peripheral neuropathy	Predictable
Dermatological	Stevens-Johnson Syndrome	Idiosyncratic
	Toxic epidermal necrolysis	Idiosyncratic
Hepatic	Colestasis, hepatitis	Idiosyncratic
Renal	Nephritis	Idiosyncratic
Pulmonary	Pneumonitis, ***PIE	Idiosyncratic
Thyroid	Hypothyroidism	Idiosyncratic

DHS = dapsone hypersensitivity syndrome, DRESS = drug rash, eosinophilia and systemic symptoms, PIE = pulmonary infiltration with eosinophilia

ISSN: 1745-6673