Table 6 Treatment approaches to DHS

1. Withdrawal of offending medication (dapsone)

Drug discontinuation

2. Supportive therapy

   • Volume replacement

Intravenous fluid replacement

   • Nutritional support

Enteral or parenteral nutrition

   • Antibiotics

Early antibiotic institution in case of concomitant sepsis

   • Skin care

Preventing skin superinfection

3. Specific therapy

   • Glucocorticoids

Recommended dose 1 mg/kg/day

   • Thyroid hormone replacement

Associated late hypothyroidism

   • Family counseling

Genetic factors involvement