Patient A | Patient B | Patient C | Patient D | |
---|---|---|---|---|
Type of mutation | c.463+2 T>C | c.332 G>A | c.506 T>C | c.463+1 G>C |
Age at diagnosis | 52 years | 58 years | 63 years | 42 years |
Sex | man | women | man | man |
Exposure to TCE | yes | no | yes | no |
Conditions of exposure | 2 years to 15 ppm in screw cutting industry during | highly exposed (cumulative dose 830 ppm.years with peaks) | ||
Other occupational exposures identified | cutting oils asbestos | cutting oils in screw cutting industry | other chlorinated solvents, cutting oils, lead, ionizing radiations, asbestos and welding fumes | none of the exposures studied |
Tobacco smoking | 12 pack-years | never | 20 pack-years | never |
Body Mass Index | < 25 | > 30 | < 25 | between 25 and 30 |