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Table 2 Description of patient with a VHL gene mutation

From: Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma

 

Patient A

Patient B

Patient C

Patient D

Type of mutation

c.463+2 T>C

c.332 G>A

c.506 T>C

c.463+1 G>C

Age at diagnosis

52 years

58 years

63 years

42 years

Sex

man

women

man

man

Exposure to TCE

yes

no

yes

no

Conditions of exposure

2 years to 15 ppm in screw cutting industry during

 

highly exposed (cumulative dose 830 ppm.years with peaks)

 

Other occupational exposures identified

cutting oils asbestos

cutting oils in screw cutting industry

other chlorinated solvents, cutting oils, lead, ionizing radiations, asbestos and welding fumes

none of the exposures studied

Tobacco smoking

12 pack-years

never

20 pack-years

never

Body Mass Index

< 25

> 30

< 25

between 25 and 30