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Table 4 Solvent exposure and B-NHL subentities (unconditional logistic regression analysis)

From: Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

  Contr. DLBCL (n = 158) FL (n = 92) CLL (n = 104) Multiple myeloma (n = 76) Marginal zone lymphoma (n = 38)
  N N Adj. OR a 95% CI N Adj. OR a 95% CI N Adj. OR a 95% CI N Adj. OR a 95% CI N Adj. OR a 95% CI
CHLORINATED HYDROCARBONS                 
Chlorinated hydrocarbons in total [ppm*yrs.]                 
   0 ppm*yrs. 563 132 1.0 - 70 1.0 - 78 1.0 - 62 1.0 - 27 1.0 -
   >0, <= 4.4 ppm*yrs. 74 10 0.6 0.3–1.2 9 1.4 0.6–3.1 11 0.9 0.4–1.9 3 0.4 0.1–1.3 4 1.6 0.5–5.1
   >4.4, <= 47.3 ppm*yrs. 59 9 0.7 0.3–1.5 8 1.7 0.7–4.0 9 0.7 0.3–1.6 8 1.0 0.4–2.4 3 1.4 0.4–5.3
   >47.3 ppm*yrs. 14 5 1.8 0.6–5.3 5 3.9 1.3–12.1 6 1,8 0.6–4.9 2 0.9 0.2–4.4 4 7.0 1.8–26.3
Trend test*     P = 0.02    P = 0.04    P = 0.88    P = 0.15    P = 0.008
Trichloroethene [ppm*yrs.]                 
   0 ppm*yrs. 602 139 1.0 - 79 1.0 - 86 1.0 - 65 1.0 - 32 1.0 -
   >0, <= 4.4 ppm*yrs. 55 6 0.5 0.2–1.2 7 1.3 0.5–3.2 10 1.1 0.5–2.4 3 0.5 0.2–1.9 2 0.9 1.2–4.3
   >4.4, <= 35 ppm*yrs. 44 7 0.8 0.3–1.8 3 0.7 0.2–2.6 6 0.7 0.3–1.7 6 1.0 0.4–2.7 2 4.2 0.8–23.9
   >35 ppm*yrs. 9 4 2.6 0.7–3.0 3 3.2 0.8–12.9 2 0.9 0.2–4.5 1 0.7 0.1–5.5 2 4.2 0.8–23.9
Trend test*     P = 0.03    P = 0.16    P = 0.46 (neg.)    P = 0.43 (neg.)    P = 0.15
Tetrachloroethene [ppm*yrs.]                 
   0 ppm*yrs. 679 146 1.0 - 90 1.0 - 101 1.0 - 33 1.0 -   1.0 -
   >0, <= 9.1 ppm*yrs. 16 3 0.9 0.3–3.9 2 1.2 0.3–5.5 1 - - 3 1.8 0.5–6.7 1 - -
   >9.1, <= 78.8 ppm*yrs. 13 6 2.1 0.8–5.9 -    2 0.6 0.1–2.8 - - - 3 4.2 1.02–17.5
   >78.8 ppm*yrs. 2 1 2.3 0.2–26.0 -    - - - - - - 1 - -
Trend test*     P = 0.19    P = 0.43 (neg.)    P = 0.6    P = 0.34 (neg.)    P = 0.10
CTET [ppm*yrs.]                 
   0 ppm*yrs. 696 153 1.0 - 87 1.0 - 98 1.0 - 72 1.0 - 37 1.0 -
   >0, <= 2.3 ppm*yrs. 8 1 0.7 0.1–6.1 4 5.0 1.4–18.3 5 2.7 1.8–8.9 - - - - - -
   >2.3, <= 48.1 ppm*yrs. 5 2 1.6 0.3–8.9 1 2.1 0.2–19.4 - - - 3 4.5 0.57–20.9 1 3.6 0.4–34.6
   >48.1 ppm*yrs. 1 - - - - - - - - - - - - - - -
Trend test*     P = 0.75    P = 0.83    P = 0.38    P = 0.83    P = 0.98
DCM [ppm*yrs.]                 
   0 ppm*yrs. 681 150 1.0 - 88 1.0 - 100 1.0 - 74 1.0 - 36 1.0 -
   >0, <= 26.3 ppm*yrs. 16 3 0.8 0.2–2.9 1 0.5 0.1–4.3 1 0.3 0.04–2.4 - - - 1 1.5 0.2–11.9
   >26.3, <= 175 ppm*yrs. 11 2 0.9 0.2–4.2 2 1.5 0.3–7.4 2 0.8 0.2–3.9 - - - - - -
   >175 ppm*yrs. 2 1 - - 1 - - 1 - - 1 - - 1 - -
Trend test*     P = 0.45    P = 0.20    P = 0.78    P = 0.19    P = 0.10
AROMATIC HYDROCARBONS                 
Benzene [ppm*yrs.]                 
   0 ppm*yrs. 590 136 1.0 - 73 1.0 - 80 1.0 - 62 1.0 - 32 1.0 -
   >0, <= 8.6 ppm*yrs. 60 9 0.7 0.3–1.4 10 1.8 0.8–3.8 8 0.8 0.4–1.8 6 1.0 0.4–2.4 2 0.7 0.2–3.0
   >8.6, <= 130 ppm*yrs. 48 10 0.9 0.4–1.9 7 1.5 0.6–3.5 14 1.6 0.8–3.2 4 0.7 0.2–2.0 3 1.1 0.3–3.8
   >130 ppm*yrs. 12 1 0.3 0.04–2.6 2 1.3 0.3–6.4 2 0.7 0.1–3.1 3 1.8 0.5–6.8 1 1.4 0.2–11.8
Trend test*     P = 0.52 (neg.)    P = 0.51    P = 0.48    P = 0.54    P = 0.32
Toluene [ppm*yrs.]                 
   0 ppm*yrs. 545 122 1.0 - 66 1.0 - 76 1.0 - 59 1.0 - 27 1.0 -
   >0, <= 3.5 ppm*yrs. 80 18 1.1 0.6–2.0 8 1.1 0.5–2.4 11 0.9 0.4–1.8 6 0.8 0.3–1.9 4 1.0 0.3–3.3
   >3.5, <= 207 ppm*yrs. 69 14 1.0 0.5–1.9 16 2.6 1.4–5.1 15 1.3 0.7–2.4 7 0.9 0.4–2.0 6 1.9 0.7–5.1
   >207 ppm*yrs. 16 2 0.6 0.1–2.5 2 1.1 0.2–5.3 2 0.5 0.1–2.4 3 1.4 0.4–5.2 1 1.1 0.1–9.5
Trend test*     P = 0.87    P = 0.48    P = 0.48    P = 0.48    P = 0.48
Xylene [ppm*yrs.]                 
   0 ppm*yrs. 552 127 1.0 - 66 1.0 - 79 1.0 - 59 1.0 - 27 1.0 -
   >0, <= 4.4 ppm*yrs. 80 13 0.8 0.4–1.5 7 1.0 0.4–2.3 9 0.7 0.3–1.5 6 0.8 0.3–1.9 5 1.4 0.5–4.0
   >4.4, <= 230 ppm*yrs. 63 14 1.1 0.6–2.0 17 3.0 1.6–5.8 15 1.3 0.7–2.5 7 0.9 0.4–2.2 5 1.8 0.6–4.9
   >230 ppm*yrs. 15 2 0.6 0.1–2.6 2 1.3 0.3–6.2 1 0.3 0.04–2.2 3 1.5 0.4–5.8 1 1.3 0.2–10.5
Trend test*     P = 0.95    P = 0.33    P = 0.47    P = 0.36    P = 0.40
Styrene [ppm*yrs.]                 
   0 ppm*yrs. 541 117 1.0 - 60 1.0 - 81 1.0 - 60 1.0 - 31 1.0 -
   >0, <= 1.5 ppm*yrs. 85 15 0.8 0.4–1.5 12 1.1 0.5–2.1 10 1.0 0.5–2.2 6 0.8 0.3–1.9 4 1.0 0.3–3.0
   >1.5, <= 67.1 ppm*yrs. 67 19 1.3 0.7–2.3 17 2.2 1.2–4.0 11 1.1 0.5–2.2 8 1.0 0.5–2.4 3 0.8 0.2–2.6
   >67.1 ppm*yrs. 17 5 1.5 0.5–4.4 3 1.6 0.5–6.0 2 0.5 0.2–2.3 1 0.5 0.1–3.8 - - -
Trend test*     P = 0.03    P = 0.20    P = 0.37    P = 0.85    P = 0.28
  1. Missing values were included as a separate category (not shown)
  2. a Odds Ratio (OR) adjusted for age, sex, region, smoking [packyears] and alcohol consumption [g per day]
  3. * To calculate tests for trend, the exposure scores were included as continuous variables in the logistic regression model
  4. Abbreviations: OR = odds ratio; CI = confidence interval; yrs. = years