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Table 4 Solvent exposure and B-NHL subentities (unconditional logistic regression analysis)

From: Solvent exposure and malignant lymphoma: a population-based case-control study in Germany

 

Contr.

DLBCL

(n = 158)

FL

(n = 92)

CLL

(n = 104)

Multiple myeloma

(n = 76)

Marginal zone lymphoma

(n = 38)

 

N

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

N

Adj. OR a

95% CI

CHLORINATED HYDROCARBONS

                

Chlorinated hydrocarbons in total [ppm*yrs.]

                

   0 ppm*yrs.

563

132

1.0

-

70

1.0

-

78

1.0

-

62

1.0

-

27

1.0

-

   >0, <= 4.4 ppm*yrs.

74

10

0.6

0.3–1.2

9

1.4

0.6–3.1

11

0.9

0.4–1.9

3

0.4

0.1–1.3

4

1.6

0.5–5.1

   >4.4, <= 47.3 ppm*yrs.

59

9

0.7

0.3–1.5

8

1.7

0.7–4.0

9

0.7

0.3–1.6

8

1.0

0.4–2.4

3

1.4

0.4–5.3

   >47.3 ppm*yrs.

14

5

1.8

0.6–5.3

5

3.9

1.3–12.1

6

1,8

0.6–4.9

2

0.9

0.2–4.4

4

7.0

1.8–26.3

Trend test*

   

P = 0.02

  

P = 0.04

  

P = 0.88

  

P = 0.15

  

P = 0.008

Trichloroethene [ppm*yrs.]

                

   0 ppm*yrs.

602

139

1.0

-

79

1.0

-

86

1.0

-

65

1.0

-

32

1.0

-

   >0, <= 4.4 ppm*yrs.

55

6

0.5

0.2–1.2

7

1.3

0.5–3.2

10

1.1

0.5–2.4

3

0.5

0.2–1.9

2

0.9

1.2–4.3

   >4.4, <= 35 ppm*yrs.

44

7

0.8

0.3–1.8

3

0.7

0.2–2.6

6

0.7

0.3–1.7

6

1.0

0.4–2.7

2

4.2

0.8–23.9

   >35 ppm*yrs.

9

4

2.6

0.7–3.0

3

3.2

0.8–12.9

2

0.9

0.2–4.5

1

0.7

0.1–5.5

2

4.2

0.8–23.9

Trend test*

   

P = 0.03

  

P = 0.16

  

P = 0.46 (neg.)

  

P = 0.43 (neg.)

  

P = 0.15

Tetrachloroethene [ppm*yrs.]

                

   0 ppm*yrs.

679

146

1.0

-

90

1.0

-

101

1.0

-

33

1.0

-

 

1.0

-

   >0, <= 9.1 ppm*yrs.

16

3

0.9

0.3–3.9

2

1.2

0.3–5.5

1

-

-

3

1.8

0.5–6.7

1

-

-

   >9.1, <= 78.8 ppm*yrs.

13

6

2.1

0.8–5.9

-

  

2

0.6

0.1–2.8

-

-

-

3

4.2

1.02–17.5

   >78.8 ppm*yrs.

2

1

2.3

0.2–26.0

-

  

-

-

-

-

-

-

1

-

-

Trend test*

   

P = 0.19

  

P = 0.43 (neg.)

  

P = 0.6

  

P = 0.34 (neg.)

  

P = 0.10

CTET [ppm*yrs.]

                

   0 ppm*yrs.

696

153

1.0

-

87

1.0

-

98

1.0

-

72

1.0

-

37

1.0

-

   >0, <= 2.3 ppm*yrs.

8

1

0.7

0.1–6.1

4

5.0

1.4–18.3

5

2.7

1.8–8.9

-

-

-

-

-

-

   >2.3, <= 48.1 ppm*yrs.

5

2

1.6

0.3–8.9

1

2.1

0.2–19.4

-

-

-

3

4.5

0.57–20.9

1

3.6

0.4–34.6

   >48.1 ppm*yrs.

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

Trend test*

   

P = 0.75

  

P = 0.83

  

P = 0.38

  

P = 0.83

  

P = 0.98

DCM [ppm*yrs.]

                

   0 ppm*yrs.

681

150

1.0

-

88

1.0

-

100

1.0

-

74

1.0

-

36

1.0

-

   >0, <= 26.3 ppm*yrs.

16

3

0.8

0.2–2.9

1

0.5

0.1–4.3

1

0.3

0.04–2.4

-

-

-

1

1.5

0.2–11.9

   >26.3, <= 175 ppm*yrs.

11

2

0.9

0.2–4.2

2

1.5

0.3–7.4

2

0.8

0.2–3.9

-

-

-

-

-

-

   >175 ppm*yrs.

2

1

-

-

1

-

-

1

-

-

1

-

-

1

-

-

Trend test*

   

P = 0.45

  

P = 0.20

  

P = 0.78

  

P = 0.19

  

P = 0.10

AROMATIC HYDROCARBONS

                

Benzene [ppm*yrs.]

                

   0 ppm*yrs.

590

136

1.0

-

73

1.0

-

80

1.0

-

62

1.0

-

32

1.0

-

   >0, <= 8.6 ppm*yrs.

60

9

0.7

0.3–1.4

10

1.8

0.8–3.8

8

0.8

0.4–1.8

6

1.0

0.4–2.4

2

0.7

0.2–3.0

   >8.6, <= 130 ppm*yrs.

48

10

0.9

0.4–1.9

7

1.5

0.6–3.5

14

1.6

0.8–3.2

4

0.7

0.2–2.0

3

1.1

0.3–3.8

   >130 ppm*yrs.

12

1

0.3

0.04–2.6

2

1.3

0.3–6.4

2

0.7

0.1–3.1

3

1.8

0.5–6.8

1

1.4

0.2–11.8

Trend test*

   

P = 0.52 (neg.)

  

P = 0.51

  

P = 0.48

  

P = 0.54

  

P = 0.32

Toluene [ppm*yrs.]

                

   0 ppm*yrs.

545

122

1.0

-

66

1.0

-

76

1.0

-

59

1.0

-

27

1.0

-

   >0, <= 3.5 ppm*yrs.

80

18

1.1

0.6–2.0

8

1.1

0.5–2.4

11

0.9

0.4–1.8

6

0.8

0.3–1.9

4

1.0

0.3–3.3

   >3.5, <= 207 ppm*yrs.

69

14

1.0

0.5–1.9

16

2.6

1.4–5.1

15

1.3

0.7–2.4

7

0.9

0.4–2.0

6

1.9

0.7–5.1

   >207 ppm*yrs.

16

2

0.6

0.1–2.5

2

1.1

0.2–5.3

2

0.5

0.1–2.4

3

1.4

0.4–5.2

1

1.1

0.1–9.5

Trend test*

   

P = 0.87

  

P = 0.48

  

P = 0.48

  

P = 0.48

  

P = 0.48

Xylene [ppm*yrs.]

                

   0 ppm*yrs.

552

127

1.0

-

66

1.0

-

79

1.0

-

59

1.0

-

27

1.0

-

   >0, <= 4.4 ppm*yrs.

80

13

0.8

0.4–1.5

7

1.0

0.4–2.3

9

0.7

0.3–1.5

6

0.8

0.3–1.9

5

1.4

0.5–4.0

   >4.4, <= 230 ppm*yrs.

63

14

1.1

0.6–2.0

17

3.0

1.6–5.8

15

1.3

0.7–2.5

7

0.9

0.4–2.2

5

1.8

0.6–4.9

   >230 ppm*yrs.

15

2

0.6

0.1–2.6

2

1.3

0.3–6.2

1

0.3

0.04–2.2

3

1.5

0.4–5.8

1

1.3

0.2–10.5

Trend test*

   

P = 0.95

  

P = 0.33

  

P = 0.47

  

P = 0.36

  

P = 0.40

Styrene [ppm*yrs.]

                

   0 ppm*yrs.

541

117

1.0

-

60

1.0

-

81

1.0

-

60

1.0

-

31

1.0

-

   >0, <= 1.5 ppm*yrs.

85

15

0.8

0.4–1.5

12

1.1

0.5–2.1

10

1.0

0.5–2.2

6

0.8

0.3–1.9

4

1.0

0.3–3.0

   >1.5, <= 67.1 ppm*yrs.

67

19

1.3

0.7–2.3

17

2.2

1.2–4.0

11

1.1

0.5–2.2

8

1.0

0.5–2.4

3

0.8

0.2–2.6

   >67.1 ppm*yrs.

17

5

1.5

0.5–4.4

3

1.6

0.5–6.0

2

0.5

0.2–2.3

1

0.5

0.1–3.8

-

-

-

Trend test*

   

P = 0.03

  

P = 0.20

  

P = 0.37

  

P = 0.85

  

P = 0.28

  1. Missing values were included as a separate category (not shown)
  2. a Odds Ratio (OR) adjusted for age, sex, region, smoking [packyears] and alcohol consumption [g per day]
  3. * To calculate tests for trend, the exposure scores were included as continuous variables in the logistic regression model
  4. Abbreviations: OR = odds ratio; CI = confidence interval; yrs. = years