From: Solvent exposure and malignant lymphoma: a population-based case-control study in Germany
Contr. | DLBCL (n = 158) | FL (n = 92) | CLL (n = 104) | Multiple myeloma (n = 76) | Marginal zone lymphoma (n = 38) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | N | Adj. OR a | 95% CI | N | Adj. OR a | 95% CI | N | Adj. OR a | 95% CI | N | Adj. OR a | 95% CI | N | Adj. OR a | 95% CI | |
CHLORINATED HYDROCARBONS | ||||||||||||||||
Chlorinated hydrocarbons in total [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 563 | 132 | 1.0 | - | 70 | 1.0 | - | 78 | 1.0 | - | 62 | 1.0 | - | 27 | 1.0 | - |
>0, <= 4.4 ppm*yrs. | 74 | 10 | 0.6 | 0.3–1.2 | 9 | 1.4 | 0.6–3.1 | 11 | 0.9 | 0.4–1.9 | 3 | 0.4 | 0.1–1.3 | 4 | 1.6 | 0.5–5.1 |
>4.4, <= 47.3 ppm*yrs. | 59 | 9 | 0.7 | 0.3–1.5 | 8 | 1.7 | 0.7–4.0 | 9 | 0.7 | 0.3–1.6 | 8 | 1.0 | 0.4–2.4 | 3 | 1.4 | 0.4–5.3 |
>47.3 ppm*yrs. | 14 | 5 | 1.8 | 0.6–5.3 | 5 | 3.9 | 1.3–12.1 | 6 | 1,8 | 0.6–4.9 | 2 | 0.9 | 0.2–4.4 | 4 | 7.0 | 1.8–26.3 |
Trend test* | P = 0.02 | P = 0.04 | P = 0.88 | P = 0.15 | P = 0.008 | |||||||||||
Trichloroethene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 602 | 139 | 1.0 | - | 79 | 1.0 | - | 86 | 1.0 | - | 65 | 1.0 | - | 32 | 1.0 | - |
>0, <= 4.4 ppm*yrs. | 55 | 6 | 0.5 | 0.2–1.2 | 7 | 1.3 | 0.5–3.2 | 10 | 1.1 | 0.5–2.4 | 3 | 0.5 | 0.2–1.9 | 2 | 0.9 | 1.2–4.3 |
>4.4, <= 35 ppm*yrs. | 44 | 7 | 0.8 | 0.3–1.8 | 3 | 0.7 | 0.2–2.6 | 6 | 0.7 | 0.3–1.7 | 6 | 1.0 | 0.4–2.7 | 2 | 4.2 | 0.8–23.9 |
>35 ppm*yrs. | 9 | 4 | 2.6 | 0.7–3.0 | 3 | 3.2 | 0.8–12.9 | 2 | 0.9 | 0.2–4.5 | 1 | 0.7 | 0.1–5.5 | 2 | 4.2 | 0.8–23.9 |
Trend test* | P = 0.03 | P = 0.16 | P = 0.46 (neg.) | P = 0.43 (neg.) | P = 0.15 | |||||||||||
Tetrachloroethene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 679 | 146 | 1.0 | - | 90 | 1.0 | - | 101 | 1.0 | - | 33 | 1.0 | - | 1.0 | - | |
>0, <= 9.1 ppm*yrs. | 16 | 3 | 0.9 | 0.3–3.9 | 2 | 1.2 | 0.3–5.5 | 1 | - | - | 3 | 1.8 | 0.5–6.7 | 1 | - | - |
>9.1, <= 78.8 ppm*yrs. | 13 | 6 | 2.1 | 0.8–5.9 | - | 2 | 0.6 | 0.1–2.8 | - | - | - | 3 | 4.2 | 1.02–17.5 | ||
>78.8 ppm*yrs. | 2 | 1 | 2.3 | 0.2–26.0 | - | - | - | - | - | - | - | 1 | - | - | ||
Trend test* | P = 0.19 | P = 0.43 (neg.) | P = 0.6 | P = 0.34 (neg.) | P = 0.10 | |||||||||||
CTET [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 696 | 153 | 1.0 | - | 87 | 1.0 | - | 98 | 1.0 | - | 72 | 1.0 | - | 37 | 1.0 | - |
>0, <= 2.3 ppm*yrs. | 8 | 1 | 0.7 | 0.1–6.1 | 4 | 5.0 | 1.4–18.3 | 5 | 2.7 | 1.8–8.9 | - | - | - | - | - | - |
>2.3, <= 48.1 ppm*yrs. | 5 | 2 | 1.6 | 0.3–8.9 | 1 | 2.1 | 0.2–19.4 | - | - | - | 3 | 4.5 | 0.57–20.9 | 1 | 3.6 | 0.4–34.6 |
>48.1 ppm*yrs. | 1 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Trend test* | P = 0.75 | P = 0.83 | P = 0.38 | P = 0.83 | P = 0.98 | |||||||||||
DCM [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 681 | 150 | 1.0 | - | 88 | 1.0 | - | 100 | 1.0 | - | 74 | 1.0 | - | 36 | 1.0 | - |
>0, <= 26.3 ppm*yrs. | 16 | 3 | 0.8 | 0.2–2.9 | 1 | 0.5 | 0.1–4.3 | 1 | 0.3 | 0.04–2.4 | - | - | - | 1 | 1.5 | 0.2–11.9 |
>26.3, <= 175 ppm*yrs. | 11 | 2 | 0.9 | 0.2–4.2 | 2 | 1.5 | 0.3–7.4 | 2 | 0.8 | 0.2–3.9 | - | - | - | - | - | - |
>175 ppm*yrs. | 2 | 1 | - | - | 1 | - | - | 1 | - | - | 1 | - | - | 1 | - | - |
Trend test* | P = 0.45 | P = 0.20 | P = 0.78 | P = 0.19 | P = 0.10 | |||||||||||
AROMATIC HYDROCARBONS | ||||||||||||||||
Benzene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 590 | 136 | 1.0 | - | 73 | 1.0 | - | 80 | 1.0 | - | 62 | 1.0 | - | 32 | 1.0 | - |
>0, <= 8.6 ppm*yrs. | 60 | 9 | 0.7 | 0.3–1.4 | 10 | 1.8 | 0.8–3.8 | 8 | 0.8 | 0.4–1.8 | 6 | 1.0 | 0.4–2.4 | 2 | 0.7 | 0.2–3.0 |
>8.6, <= 130 ppm*yrs. | 48 | 10 | 0.9 | 0.4–1.9 | 7 | 1.5 | 0.6–3.5 | 14 | 1.6 | 0.8–3.2 | 4 | 0.7 | 0.2–2.0 | 3 | 1.1 | 0.3–3.8 |
>130 ppm*yrs. | 12 | 1 | 0.3 | 0.04–2.6 | 2 | 1.3 | 0.3–6.4 | 2 | 0.7 | 0.1–3.1 | 3 | 1.8 | 0.5–6.8 | 1 | 1.4 | 0.2–11.8 |
Trend test* | P = 0.52 (neg.) | P = 0.51 | P = 0.48 | P = 0.54 | P = 0.32 | |||||||||||
Toluene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 545 | 122 | 1.0 | - | 66 | 1.0 | - | 76 | 1.0 | - | 59 | 1.0 | - | 27 | 1.0 | - |
>0, <= 3.5 ppm*yrs. | 80 | 18 | 1.1 | 0.6–2.0 | 8 | 1.1 | 0.5–2.4 | 11 | 0.9 | 0.4–1.8 | 6 | 0.8 | 0.3–1.9 | 4 | 1.0 | 0.3–3.3 |
>3.5, <= 207 ppm*yrs. | 69 | 14 | 1.0 | 0.5–1.9 | 16 | 2.6 | 1.4–5.1 | 15 | 1.3 | 0.7–2.4 | 7 | 0.9 | 0.4–2.0 | 6 | 1.9 | 0.7–5.1 |
>207 ppm*yrs. | 16 | 2 | 0.6 | 0.1–2.5 | 2 | 1.1 | 0.2–5.3 | 2 | 0.5 | 0.1–2.4 | 3 | 1.4 | 0.4–5.2 | 1 | 1.1 | 0.1–9.5 |
Trend test* | P = 0.87 | P = 0.48 | P = 0.48 | P = 0.48 | P = 0.48 | |||||||||||
Xylene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 552 | 127 | 1.0 | - | 66 | 1.0 | - | 79 | 1.0 | - | 59 | 1.0 | - | 27 | 1.0 | - |
>0, <= 4.4 ppm*yrs. | 80 | 13 | 0.8 | 0.4–1.5 | 7 | 1.0 | 0.4–2.3 | 9 | 0.7 | 0.3–1.5 | 6 | 0.8 | 0.3–1.9 | 5 | 1.4 | 0.5–4.0 |
>4.4, <= 230 ppm*yrs. | 63 | 14 | 1.1 | 0.6–2.0 | 17 | 3.0 | 1.6–5.8 | 15 | 1.3 | 0.7–2.5 | 7 | 0.9 | 0.4–2.2 | 5 | 1.8 | 0.6–4.9 |
>230 ppm*yrs. | 15 | 2 | 0.6 | 0.1–2.6 | 2 | 1.3 | 0.3–6.2 | 1 | 0.3 | 0.04–2.2 | 3 | 1.5 | 0.4–5.8 | 1 | 1.3 | 0.2–10.5 |
Trend test* | P = 0.95 | P = 0.33 | P = 0.47 | P = 0.36 | P = 0.40 | |||||||||||
Styrene [ppm*yrs.] | ||||||||||||||||
0 ppm*yrs. | 541 | 117 | 1.0 | - | 60 | 1.0 | - | 81 | 1.0 | - | 60 | 1.0 | - | 31 | 1.0 | - |
>0, <= 1.5 ppm*yrs. | 85 | 15 | 0.8 | 0.4–1.5 | 12 | 1.1 | 0.5–2.1 | 10 | 1.0 | 0.5–2.2 | 6 | 0.8 | 0.3–1.9 | 4 | 1.0 | 0.3–3.0 |
>1.5, <= 67.1 ppm*yrs. | 67 | 19 | 1.3 | 0.7–2.3 | 17 | 2.2 | 1.2–4.0 | 11 | 1.1 | 0.5–2.2 | 8 | 1.0 | 0.5–2.4 | 3 | 0.8 | 0.2–2.6 |
>67.1 ppm*yrs. | 17 | 5 | 1.5 | 0.5–4.4 | 3 | 1.6 | 0.5–6.0 | 2 | 0.5 | 0.2–2.3 | 1 | 0.5 | 0.1–3.8 | - | - | - |
Trend test* | P = 0.03 | P = 0.20 | P = 0.37 | P = 0.85 | P = 0.28 |