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Table 3 Cancer risks (incidence rate ratios RR) in women with residence in communities with a large or medium area under wine cultivation vs. women in communities with low area under wine cultivation

From: Cancer risk among residents of Rhineland-Palatinate winegrowing communities: a cancer-registry based ecological study

 

Reference* (1,778,184 PY†)

Area under wine cultivation > 5, ≤ 20% of community area (1,098,069 PY†)

Area under wine cultivation > 20% of community area (634,060 PY†)

ICD-10 code

Cases

Cases

RR‡§

95% CI

Cases

RR‡§

95% CI

Head & neck (C00–C14)

123

70

1.05

0.74–1.50

41

1.14

0.75–1.74

Other and unspecified parts of tongue (C02)

14

8

1.01

0.41–2.48

6

1.56

0.52–4.64

Oropharynx (C10)

19

6

0.53

0.20–1.39

5

0.81

0.28–2.39

Oesophagus (C15)

38

17

0.89

0.46–1.70

9

0.91

0.40–2.08

Stomach (C16)

197

147

1.27

1.01–1.60

61

1.07

0.79–1.47

Small intestine (C17)

24

17

1.17

0.64–2.15

8

1.04

0.45–2.40

Colon, sigmoid & rectum (C18–C21)

1122

733

1.04

0.92–1.17

346

0.94

0.81–1.09

Colon (C18)

734

509

1.11

0.97–1.28

214

0.90

0.75–1.08

Rectosigmoid junction (C19)

64

32

0.78

0.51–1.21

20

0.86

0.50–1.48

Rectum (C20)

301

180

0.95

0.78–1.17

108

1.06

0.83–1.35

Anus and anal canal (C21)

23

12

0.89

0.44–1.81

4

0.60

0.20–1.83

Liver and intrahepatic bile ducts (C22)

43

32

1.17

0.72–1.90

19

1.20

0.66–2.19

Gallbladder & biliary tract (C23–C24)

79

58

1.13

0.79–1.61

19

0.64

0.38–1.09

Gallbladder (C23)

39

38

1.44

0.89–2.33

10

0.64

0.30–1.34

Other and unspecified parts of biliary tract (C24)

40

20

0.78

0.46–1.34

9

0.63

0.29–1.34

Pancreas (C25)

158

85

0.97

0.72–1.29

40

0.93

0.64–1.37

Larynx (C32)

19

12

0.99

0.47–2.07

4

0.56

0.18–1.75

Trachea, bronus and lung (C33–C34)

342

168

0.99

0.77–1.27

94

1.19

0.88–1.59

Bronchus and lung (C34)

340

167

0.99

0.77–1.27

94

1.19

0.89–1.60

Skin, malignant melanoma (C43)

274

212

1.17

0.96–1.42

109

1.00

0.78–1.28

Skin, other malignant neoplasms (C44)

1710

1620

1.40

1.27–1.54

807

1.38

1.23–1.53

Retroperitoneum and peritoneum (C48)

10

9

1.72

0.65–4.53

4

1.93

0.53–7.02

Other connective and soft tissue (C49)

30

17

0.98

0.54–1.79

9

1.03

0.46–2.32

Breast (C50)

2525

1527

1.08

0.98–1.20

779

1.01

0.90–1.12

Vulva (C51)

63

36

0.98

0.64–1.50

22

1.23

0.72–2.10

Vagina (C52)

18

20

1.80

0.94–3.45

5

0.82

0.29–2.33

Cervix uteri (C53)

162

97

1.03

0.79–1.34

47

0.94

0.66–1.34

Corpus uteri, (C54–C55)

382

244

1.15

0.94–1.41

146

1.20

0.95–1.52

Corpus uteri (C54)

370

232

1.13

0.92–1.39

144

1.22

0.97–1.54

Uterus, part unspecified (C55)

12

12

1.58

0.70–3.59

2

0.46

0.10–2.17

Ovary and other unspecified female genital organs (C56–C57)

297

196

1.09

0.89–1.34

96

0.97

0.75–1.26

Ovary (C56)

284

183

1.07

0.86–1.32

93

0.99

0.76–1.28

Other and unspecified female genital organs (C57)

13

13

1.66

0.76–3.63

3

0.73

0.19–2.72

Urinary tract (C64-C66+C68)

208

136

1.10

0.86–1.40

73

1.04

0.77–1.40

Kidney, except renal pelvis (C64)

166

116

1.14

0.88–1.48

63

1.09

0.79–1.50

Renal pelvis (C65)

24

10

0.71

0.33–1.49

4

0.55

0.18–1.71

Ureter (C66)

16

10

1.02

0.45–2.29

4

0.75

0.23–2.44

Bladder (C67, D09.0, D41.4)

251

158

1.09

0.88–1.34

85

1.19

0.90–1.56

Brain, CNS, meninges (C70–C72, D32–33, D42–43)

167

105

1.11

0.84–1.46

62

1.25

0.89–1.75

Meninges (C70)

57

46

1.33

0.87–2.03

24

1.29

0.75–2.21

Brain (C71, D33, D43)

107

57

0.98

0.68–1.40

37

1.21

0.79–1.86

Thyroid gland (C73)

102

75

1.20

0.86–1.67

32

0.86

0.56–1.34

Hodgkin's disease (C81)

39

20

0.83

0.48–1.44

9

0.64

0.29–1.39

NHL (C82–C85)

220

114

0.93

0.72–1.21

52

0.78

0.56–1.09

Follicular NHL (C82)

50

18

0.58

0.34–1.01

5

0.29

0.11–0.76

Diffuse NHL (C83)

106

69

1.05

0.76–1.45

25

0.73

0.46–1.17

Other and unspecified types of NHL (C85)

56

24

0.71

0.43–1.14

19

1.07

0.61–1.89

Multiple myeloma (C90)

68

30

0.72

0.46–1.13

21

0.88

0.51–1.49

Leukaemia (C91–C95)

135

65

0.80

0.59–1.09

43

0.98

0.68–1.43

Lymphoid leukaemia (C91)

67

33

0.78

0.51–1.18

22

0.90

0.54–1.50

Myeloid leukaemia (C92)

60

32

0.90

0.59–1.37

16

0.92

0.51–1.66

Primary site unspecified

116

78

1.18

0.90–1.56

36

1.13

0.76–1.68

All malignancies (excluding C44)

7258

4508

1.09

1.03–1.17

2293

1.04

0.97–1.11

All malignancies (including C44)

8968

6128

1.14

1.08–1.21

3100

1.10

1.04–1.17

  1. * Winegrowing communities with >0, <= 5% area under wine cultivation
  2. † PY: Person-Years were approximated by population figures: the sum of population at the end of the year in the years under consideration.
  3. ‡ adjusted for age, rural or urban environment, and fruit cultivation
  4. § Poisson distribution of case counts assumed for: C21, C52, C55, C57, C65, C81
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Journal of Occupational Medicine and Toxicology

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