Figure 3From: Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathwaysEffect of PD98059 (MEK 1 inhibitor) on TPTC-induced disruption of GJIC in WB-F344 cells (mean values ± S.D.). The control group comprises negative controls. The PD98059 group comprises cells treated with 50 μM PD98059 for 30 min. The TPTC group comprises cells treated with 1.5 ppm TPTC for 30 min. The PD98059 + TPTC group comprises cells pre-treated with 50 μM PD98059 for 30 min and then exposed to 1.5 ppm TPTC for 30 min. Asterisks indicate statistically significant difference. (# p < 0.05 compared with the control group, *p < 0.05 compared with the group exposed to PD98059 alone, and &p < 0.05 compared with the group exposed to TPTC alone.)Back to article page