Leupeptin reduces impulse noise induced hearing loss

Table 1 Assessment of toxicity of various concentrations of leupeptin and other agents on ABR thresholds before and 3 days after middle ear application for 5 consecutive days.

Agent	Concentration	No Ears	ABR Threshold (dB pe SPL)*		Clinical observation
			Baseline	After Application
Leupeptin	15%	3**	55	120	Ipsilateral head tilt, bloody otorrhea
	1%	2	55	115	Bloody otorrhea
	0.1%	3**	56.7	60	Bloody otorrhea
	0.01%	3**	50	55
Gentamicin	4%	6	50	111.6
Saline	0.9%	6	50	56.7

ISSN: 1745-6673