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Table 2 Biochemistry Values of Rats Exposed to CD gas for 6 Months

From: Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats

Group Control Low High
Analyte Male Female Male Female Male Female
AST (U/l) 115.3 ± 34.7 140.6 ± 64.3 99.6 ± 20.0 115.5 ± 21.8 99.7 ± 22.1 179.6 ± 178.5
ALT (U/l) 37.5 ± 10.5 55.7 ± 39.6 33.4 ± 7.5 38.1 ± 11.1 38.8 ± 15.7 82.8 ± 116.4
γ-GTP (U/l) 1.0 ± 0.0 1.1 ± 0.3 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0 1.0 ± 0.0
TP (g/dl) 6.2 ± 0.2 7.3 ± 0.6 6.0 ± 0.4 7.3 ± 0.4 6.2 ± 0.2 7.2 ± 0.6
ALB (g/dl) 2.3 ± 0.1 3.0 ± 0.3 2.2 ± 0.1 3.1 ± 0.2 2.3 ± 0.1 3.1 ± 0.3
A/G 0.58 ± 0.03 0.72 ± 0.07 0.58 ± 0.04 0.74 ± 0.04 0.60 ± 0.04 0.76 ± 0.06
BG (mg/dl) 137.4 ± 11.3 137.1 ± 24.6 135.3 ± 27.6 131.2 ± 14.7 132.7 ± 13.0 129.2 ± 16.3
TC (mg/dl) 75.2 ± 14.2 87.5 ± 26.2 67.3 ± 18.2 101.6 ± 23.0 76.2 ± 16.0 88.5 ± 29.3
TG (mg/dl) 71.0 ± 19.4 84.4 ± 50.1 61.1 ± 21.9 118.6 ± 65.7 64.9 ± 32.9 69.1 ± 36.0
BUN (mg/dl) 14.1 ± 2.1 13.1 ± 1.6 14.0 ± 1.9 13.6 ± 2.3 15.4 ± 2.1 15.2 ± 0.9*
CRE (mg/dl) 0.33 ± 0.03 0.38 ± 0.05 0.33 ± 0.05 0.35 ± 0.02 0.36 ± 0.03 0.36 ± 0.02
CRP (mg/dl) 0.03 ± 0.00 0.03 ± 0.00 0.03 ± 0.00 0.03 ± 0.00 0.03 ± 0.00 0.03 ± 0.00
P (mg/l) 6.3 ± 0.4 5.8 ± 0.4 6.2 ± 0.5 5.3 ± 0.7 6.2 ± 0.4 6.1 ± 0.8
Ca (mg/l) 10.3 ± 0.31 1.2 ± 0.6 9.9 ± 0.2* 11.0 ± 0.2 10.3 ± 0.3 11.2 ± 0.6
Na (mEq/l) 143.6 ± 1.0 141.6 ± 1.5 143.5 ± 1.5 141.5 ± 1.5 143.7 ± 0.9 142.0 ± 1.2
K (mEq/l) 4.6 ± 0.2 4.8 ± 0.6 4.7 ± 0.2 4.4 ± 0.3 4.6 ± 0.2 4.6 ± 0.6
Cl (mEq/l) 104.6 ± 1.4 102.6 ± 2.4 105.1 ± 0.7 102.2 ± 1.2 103.9 ± 1.7 102.1 ± 2.0
PT (sec) 15.9 ± 2.0 10.6 ± 0.6 15.0 ± 1.6 10.7 ± 0.7 15.6 ± 1.7 11.6 ± 3.2
APTT (sec) 22.7 ± 3.1 24.9 ± 6.0 20.6 ± 2.1 22.5 ± 3.1 21.1 ± 2.3 24.0 ± 12.5
IL-6 (pg/ml) ND ND ND ND 63.8 ± 24.1 ND
TNF-α (pg/ml) ND ND ND ND ND ND
  1. Each value represents mean ± standard deviation of 10 rats
  2. * Significantly different from control, p < 0.05
  3. ND: Not detected (below the lower quantification limit: TNF-α; < 12.5 pg/ml, IL-6; < 62.5 pg/ml)