|  | Age | TSFEf | exposure duration | Cumulative exposure (fibre years) | Pack years | |
---|---|---|---|---|---|---|---|
 |  | (years) | (years) | (years) | >1 & <25 vs. ≤ 1b≥25 vs. ≤1c |  | |
 | Model a | OR d / CI | OR d / CI | OR d / CI | OR / CI | OR / CI | OR d / CI |
 |  | p | p | p | p | p | p |
Any changes | m1 | 1.86 / 1.67-2.07 | - | - | 1.23 / 0.93-1.61 | 1.51 / 1.12-2.04 | 1.06 / 1.01-1.10 |
n = 422 (13.8 %) |  | <0.0001 |  |  | 0.1433 | 0.0069 | 0.0138 |
 | m2 | - | 1.68 / 1.51-1.86 | - | 1.19 / 0.90-1.55 | 1.35 / 0.99-1.83 | 1.07 / 1.02-1.11 |
 |  |  | <0.0001 |  | 0.2183 | 0.0505 | 0.0045 |
 | m3 | - | - | 1.71 / 1.53-1.92 | 1.17 / 0.89-1.53 | 1.29 / 0.95-1.75 | 1.06 / 1.02-1.11 |
 |  |  |  | <0.0001 | 0.2554 | 0.1048 | 0.0071 |
Asbestosis | m1 | 3.22 / 2.11-4.92 | - | - | 0.32 / 0.12-0.82e | 1.20 / 0.53-2.70 | 1.16 / 1.02-1.31 |
n = 32 (1.0 %) |  | <0.0001 |  |  | 0.0186 | 0.6617 | 0.0216 |
 | m2 | - | 2.01 / 1.41-2.86 | - | 0.31 / 0.12-0.80e | 0.99 / 0.44-2.27 | 1.17 / 1.04-1.33 |
 |  |  | <0.0001 |  | 0.0154 | 0.9874 | 0.0125 |
 | m3 | - | - | 2.13 / 1.45-3.12 | 0.30 / 0.11-0.78e | 0.90 / 0.39-2.09 | 1.16 / 1.03-1.32 |
 |  |  |  | <0.0001 | 0.0131 | 0.8042 | 0.0169 |
Plaques | m1 | 1.84 / 1.61-2.10 | - | - | 1.43 / 1.01-2.05 | 1.64 / 1.11-2.42 | 1.03 / 0.98-1.09 |
n = 242 (7.9 %) |  | <0.0001 |  |  | 0.0470 | 0.0128 | 0.2536 |
 | m2 | - | 1.70 / 1.49-1.93 | - | 1.38 / 0.97-1.97 | 1.45 / 0.98-2.15 | 1.04 / 0.99-1.10 |
 |  |  | <0.0001 |  | 0.0754 | 0.0659 | 0.1538 |
 | m3 | - | - | 1.69 / 1.47-1.95 | 1.37 / 0.96-1.96 | 1.40 / 0.94-2.09 | 1.04 / 0.98-1.10 |
 |  |  |  | <0.0001 | 0.0821 | 0.1000 | 0.1939 |
Diffuse pleural thickening | m1 | 1.67 / 1.44-1.94 | - | - | 1.20 / 0.81-1.78 | 1.42 / 0.93-2.19 | 1.06 / 1.00-1.13 |
n = 180 (5.9 %) |  | <0.0001 |  |  | 0.3542 | 0.1080 | 0.0482 |
 | m2 | - | 1.56 / 1.35-1.81 | - | 1.17 / 0.79-1.73 | 1.29 / 0.83-2.00 | 1.07 / 1.01-1.14 |
 |  |  | <0.0001 |  | 0.4396 | 0.2600 | 0.0267 |
 | m3 | - | - | 1.60 / 1.36-1.89 | 1.15 / 0.78-1.71 | 1.23 / 0.79-1.91 | 1.07 / 1.01-1.14 |
 |  |  |  | <0.0001 | 0.4830 | 0.3717 | 0.0344 |