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Table 3 NCI FA cohort, NPC SMR results, local comparisons, by FA exposure, update and plant group

From: An updated re-analysis of the mortality risk from nasopharyngeal cancer in the National Cancer Institute formaldehyde worker cohort study

 

Highest Peak Categorya

AIEb

 

Cumulative Exposure (Cum)b

Duration of Exposure (Dur)b

Metricc,d

2004 NCI

1994 NCI f

2004 NCI

1994 NCI f

Metricc,d

2004 NCI

1994 NCI f

2004 NCI

1994 NCI f

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

Obs

SMRe

95 % CI

All Plants

All Plants

 NCI Cats.

 NCI Cats.

Unexposed

2

1.98

(0.24–7.16)

2

2.22

(0.27–8.00)

2

1.51

(0.18, 5.46)

2

1.62

(0.20–5.84)

Unexposed

2

1.51

(0.18–5.46)

2

1.62

(0.20–5.84)

2

1.51

(0.18–5.46)

2

1.62

(0.20–5.84)

  Exp Cat 1

1

1.03

(0.03–5.73)

0

0

(0.00–2.46)

1

0.41

(0.01, 2.28)

0

--

(0.00–1.77)

  Exp Cat 1

4

1.50

(0.41–3.83)

3

1.36

(0.28–3.97)

5

1.83

(0.59–4.26)

4

1.80

(0.49–4.62)

  Exp Cat 2

0

--

(0.00, 2.24)

0

0

(0.00–3.47)

1

0.91

(0.02, 5.09)

1

1.17

(0.03–6.50)

  Exp Cat 2

1

1.05

(0.03–5.82)

1

1.25

(0.03–6.98)

1

0.98

(0.02–5.45)

1

1.07

(0.03–5.96)

  Exp Cat 3

7

3.89**

(1.56–8.01)

7

4.84**

(1.94–9.97)

6

6.67**

(2.81, 14.42)

6

8.36**

(3.07–18.21)

  Exp Cat 3

3

3.75

(0.77–10.96)

3

4.57

(0.94–13.37)

2

2.86

(0.35–10.32)

2

3.94

(0.48–14.25)

 UPitt Cats.

 UPitt Cats.

Unexposed

2

1.98

(0.24–7.16)

2

2.22

(0.27–8.00)

2

1.51

(0.18, 5.46)

2

1.62

(0.20–5.84)

Unexposed

2

1.51

(0.18–5.46)

2

1.62

(0.20–5.84)

2

1.51

(0.18–5.46)

2

1.62

(0.20–5.84)

  Exp Cat 1

1

1.03

(0.03–5.73)

0

--

(0.00–2.46)

4

1.11

(0.30, 2.83)

3

0.99

(0.20–2.90)

  Exp Cat 1

4

1.86

(0.51–4.77)

3

1.69

(0.35–4.94)

3

2.32

(0.48–6.77)

3

2.88

(0.40–8.43)

  Exp Cat 2

0

--

(0.00, 2.24)

0

--

(0.00–3.47)

2

6.33

(0.77, 22.86)

2

7.60

(0.92–27.46)

  Exp Cat 2

2

1.08

(0.13–3.89)

2

1.30

(0.16–4.68)

3

1.83

(0.38–5.36)

2

1.49

(0.18–5.38)

  Exp Cat 3

8

4.50**

(1.94–8.87)

8

5.53**

(2.39–10.90)

3

5.73*

(1.18, 16.75)

3

8.06*

(1.66–23.55)

  Exp Cat 3

3

6.60*

(1.36–19.30)

3

8.80*

(1.82–25.73)

3

1.96

(0.41–5.74)

3

2.35

(0.48–6.86)

Plant 1

Plant 1

 UPitt Cats.

 UPitt Cats.

Unexposed

0

--

(0.00, 2.09)

0

0

(0.00–24.59)

0

--

(0.00, 14.20)

0

--

(0.00–15.97)

Unexposed

0

--

(0.00–14.20)

0

--

(0.00–15.97)

0

--

(0.00–14.20)

0

--

(0.00–15.97)

  Exp Cat 1

0

--

(0.00, 2.90)

0

--

--

2

4.88

(0.59, 17.61)

2

7.46

(0.90–26.94)

  Exp Cat 1

3

8.26*

(1.70–24.14)

3

11.70**

(2.41–34.18)

3

9.14**

(1.89–26.72)

3

12.79**

(2.64–37.37)

  Exp Cat 2

0

--

(0.00, 2.90)

0

--

(0.00–13.54)

2

10.74*

(1.30, 38.79)

2

13.96*

(1.69–50.44)

  Exp Cat 2

2

5.24

(0.63–18.93)

2

7.21

(0.87–26.04)

2

6.30

(0.76–22.75)

2

9.01*

(1.09–32.54)

  Exp Cat 3

6

12.91**

(4.74–28.10)

6

17.04**

(6.25–37.08)

2

9.03*

(1.09, 32.64)

2

11.78*

(1.43–42.57)

  Exp Cat 3

1

13.66

(0.34–76.10)

1

21.18

(0.53–118.03)

1

5.80

(0.15–32.34)

1

8.03

(0.20–44.75)

Plants 2–10

Plants 2–10

 UPitt Cats.

 UPitt Cats.

Unexposed

2

2.42

(0.29–8.75)

2

2.66

(0.32–9.60)

2

1.88

(0.23, 6.80)

2

1.99

(0.24–7.18)

Unexposed

2

1.88

(0.23–6.80)

2

1.99

(0.24–7.19)

2

1.88

(0.23–6.80)

2

1.99

(0.24–7.18)

  Exp Cat 1

1

1.04

(0.03–5.77)

0

--

(0.00–2.46)

2

0.62

(0.08, 2.25)

1

0.36

(0.01–2.02)

  Exp Cat 1

1

0.56

(0.01–3.12)

0

--

(0.00–2.43)

0

--

(0.00–3.82)

0

--

(0.00–4.58)

  Exp Cat 2

0

--

(0.00, 2.90)

0

--

(0.00–4.66)

0

--

(0.00, 28.43)

0

--

(0.00–30.78)

  Exp Cat 2

0

--

(0.00–2.50)

0

--

(0.00–2.92)

1

0.76

(0.02–4.23)

0

--

(0.00–3.29)

  Exp Cat 3

2

1.52

(0.18–5.50)

2

1.83

(0.22–6.60)

1

3.31

(0.08, 18.45)

1

4.94

(0.12–27.50)

  Exp Cat 3

2

5.25

(0.64–18.96)

2

6.81

(0.82–24.61)

2

1.48

(0.18–5.33)

2

1.73

(0.21–6.26)

  1. aNCI categories based on 60 and 80th percentiles of formaldehyde exposure among cancer deaths who were exposed. Includes only 10/11 deaths
  2. bUniversity of Pittsburgh categories based on approx. tertiles of formaldehyde exposure among NPC deaths who were exposed. Include 11 deaths
  3. cAll exposures lagged 15 years as in NCI study
  4. dNCI exposure category cutpoints: highest peak (>0- < 2.0, 2.0- < 4.0, and 4.0+ ppm); average intensity of exposure (>0-0.5, 0.5- < 1.0, and 1.0+ ppm); cumulative exposure (>0-1.5, 1.5- < 5.5, and 5.5+ ppm-years); duration of exposure (>0- < 5.0, 5.0- < 15.0, and 15.0+ years). UPitt exposure category cutpoints: highest peak (same as NCI) (>0- < 2.0, 2.0- < 4.0, and 4.0+ ppm); average intensity of exposure (<1.046, 1.046-1.177, and 1.178+ ppm); cumulative exposure (<0.734, 0.734-10.150, and 10.151+ ppm-years); duration of exposure (<0.617, 0.617-6.263, and 6.264+ years)
  5. eAll SMRs adjusted for sex, race, age group, and time period
  6. fFrom Marsh and Youk (2005)
  7. *p < 0.05, **p < 0.01
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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673