Fig. 3
From: Fipronil induces lung inflammation in vivo and cell death in vitro
Toll-like receptor 4 expression in mice lungs. Lungs from control groups (a-b and) show strong staining (arrows) in bronchiolar epithelium (B) and alveolar septum. Note rich cytoplasmic staining in bronchiolar epithelial cells (b and inset). The lungs sections (c-d) from mice treated orally with fipronil show barely minimal staining (arrows) in alveolar septum (c) while it is nearly absent in bronchiolar (B) epithelium. Lung sections from mice exposed to fipronil (e-g) show TLR4 staining similar (arrows) to the control lungs in alveolar septum (e) and epithelium (arrows) of bronchioles (B, f). Note TLR4 staining (3 g) in endothelium (arrow) and adhering cells (lightening arrows). Bar = 100 μm