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Table 1 Maximal airway constriction and EC50 concentrations of methacholine at different days of cultured human PCLS

From: Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

Days of incubation

1

5

8

12

14

15

Maximal constriction [% IAA]

0.426

11

20

20

17

19

EC50 [×10−9 M]

0.37

4

1

47

10

38

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Journal of Occupational Medicine and Toxicology

ISSN: 1745-6673