Table 1 Occupational AA-related BC cases and other BC cases by DNA adducts, age, smoking categories, pack-years, coffee consumption and genotypes
Variables | 15 AA-related BC cases | 184 other BC cases | |||
|---|---|---|---|---|---|
Mean (SD) | Number (%) | Mean (SD) | Number (%) | ||
DNA adducts×108 nucleotides (ln) | 1.40 (1.5) | 0.76 (1.2) | |||
≥1 | 11 (73.3) | 69 (37.5) | |||
Age (years) | 60.0 (10.4) | 63.4 (11.2) | |||
≤ 56.9 years | 7 (46.7) | 43 (23.4) | |||
57–65.9 years | 3 (20.0) | 50 (27.2) | |||
66–70.9 years | 3 (20.0) | 44 (23.9) | |||
≥ 71 years | 2 (13.3) | 47 (25.5) | |||
Smoking (categories) | |||||
Non Smokers & Ex Smokers quitting >20 years | 2 (13.3) | 35 (19.0) | |||
Ex Smokers quitting <20 years | 1 (6.7) | 60 (32.6) | |||
Current smokers | 12 (75.0) | 87 (47.3) | |||
Pack years (cigarettes smoked lifetime) | 31.5 (12.3) | 35.6 (26.2) | |||
≤ 18.9 | 1 (6.7) | 46 (25.1) | |||
19–32.9 | 8 (53.3) | 45 (24.6) | |||
33–46.9 | 4 (26.7) | 46 (24.6) | |||
≥ 47 | 2 (13.3) | 47 (25.7) | |||
Coffee consumption (weighted mean) | 2.1 (1.7) | 2.4 (2.4) | |||
≤ 1 cup/day | 6 (40.0) | 71 (38.8) | |||
2 cups/day | 4 (26.7) | 36 (19.7) | |||
3 caps/day | 3 (20.0) | 32 (17.5) | |||
≥ 4 cups/day | 2 (13.3) | 44 (24.0) | |||
Genotypes (legend below) | GSTM1 | 12 (80.0) | 117 (63.9) | ||
GSTT1 | 3 (20.0) | 38 (20.8) | |||
GSTP | 5 (33.3) | 92 (50.3) | |||
NAT1 | 4 (26.7) | 60 (32.8) | |||
NAT2 | 10 (66.7) | 111 (60.7) | |||
MPO | 1 (6.7) | 6 (3.3) | |||
COMT | 7 (46.7) | 132 (72.1) | |||
MnSOD | 4 (26.7) | 63 (34.4) | |||
CYP1B1 | 12 (80.0) | 156 (82.3) | |||
XRCC1 | 7 (46.7) | 98 (53.4) | |||
XRCC3 | 6 (40.0) | 103 (56.3) | |||
XPD | 7 (46.7) | 113 (61.8) | |||