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Table 3 Summary of univariate and logistic regression analysis for variables regarding treatment response SVR12 (n = 180)

From: Hepatitis C in healthcare personnel: secondary data analysis of therapies with direct-acting antiviral agents

Univariate analysis

     

Variable

Missing values

n total

% SVR12 rates

OR (95% CI)

p-value

 Cirrhosis (no/yes)

28

152 (102/50)

98% versus 86%

0.12 (0.03–0.62)

< 0.01

 Treatment (naive/experienced)

21

159 (45/114)

97.8% versus 93.9%

0.35 (0.04–2.90)

NS

 RWA (≤50%/> 50%)

5

175 (139/36)

97.1% versus 86.1%

0.18 (0.05–0.72)

< 0.05

 Gender (women/men)

0

180 (133/47)

96.2% versus 87.5%

0.32 (0.09–1.19)

NS

Multivariate logistical regression model with SVR12 as end point

Variable

Missing values

n total

OR (95% CI)

p-value

R2

 Cirrhosis (no/yes)

34

146 (98/48)

0.098 (0.01–0.75)

< 0.05

0.242

 Treatment (naive/experienced)

34

146 (42/104)

0.42 (0.05–3.92)

NS

 Gender (women/men)

34

146 (112/34)

0.41 (0.08–2.18)

NS

 Agea

34

146

1.11 (1.01–1.23)

< 0.05

  1. SVR12 sustained virologic response twelve weeks after therapy, RWA reduced work ability; Dependent variables - the first category is established as a reference;
  2. aas a continuous variable; OR (odds ratio) for the primary end point of SVR12; NS non-significant