Genome-wide mRNA profiling identifies the NRF2-regulated lymphocyte oxidative stress status in patients with silicosis

Table 3 The screened 27 DEGs associated with lymphocyte oxidative stress state by GSEA analysis of NRF2. 27 key DEGs were identified from 1158 DEGs, which belong to the gene sets from GSH metabolism, the TGF-β signaling pathway, and ECM receptor interaction signaling pathway

Gene Symbol	Description	Log₂FC	t	P.Value
GCLC	glutamate-cysteine ligase catalytic subunit	0.9761	3.5071	0.0130
THBS1	thrombospondin 1	1.8189	3.3611	0.0155
ITGA2B	integrin subunit alpha 2b	1.4937	7.8035	0.0003
BMP6	bone morphogenetic protein 6	1.4981	3.6512	0.0110
ZFYVE9	zinc finger FYVE-type containing 9	−1.2890	−2.8443	0.0299
ITGA2	integrin subunit alpha 2	1.1618	2.6027	0.0410
GP9	glycoprotein IX platelet	1.2380	4.6464	0.0036
ITGA4	integrin subunit alpha 4	−1.7863	−3.3991	0.0148
CD44	CD44 molecule	−1.2415	−4.3524	0.0050
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	−0.6038	−2.5541	0.0438
TGFB2	transforming growth factor beta 2	1.5877	2.6729	0.0374
GSTM4	glutathione S-transferase mu 4	1.8561	2.4830	0.0482
GCLM	glutamate-cysteine ligase modifier subunit	0.6821	2.5854	0.0420
SDC4	syndecan 4	0.6770	2.7085	0.0357
AGRN	agrin	0.9977	2.8008	0.0316
MAPK3	mitogen-activated protein kinase 3	0.8754	2.5837	0.0421
ODC1	ornithine decarboxylase 1	0.7449	2.9195	0.0271
ACVR1	activin A receptor type 1	1.8224	2.9468	0.0261
GP6	glycoprotein VI platelet	1.2393	3.1317	0.0207
LTBP1	latent transforming growth factor beta binding protein 1	1.6414	4.7492	0.0033
BMPR1B	bone morphogenetic protein receptor type 1B	−2.4111	−2.7113	0.0355
GSR	glutathione-disulfide reductase	0.7830	2.6736	0.0374
SP1	SP1 transcription factor	1.1197	2.5086	0.0465
ITGB3	integrin subunit beta 3	1.1695	4.6047	0.0038
GP1BA	glycoprotein IB platelet alpha subunit	0.8702	2.7218	0.0351
MGST3	microsomal glutathione S-transferase 3	0.7892	2.9403	0.0264
SRM	spermidine synthase	−1.2838	−3.3023	0.0167