Table 1 Studies in which FeNO was utilized as surrogate endpoint of an intervention in a workplace with potential risk of occupational asthma.
From: The value of fractional exhaled nitric oxide in occupational diseases – a systematic review
Exposure/occupation | Comparator | No pf participants | Type of intervention | Main results | |
|---|---|---|---|---|---|
Al Badri F.M. et al.,2020 [31] | Flour/bakers | 2 types of interventions vs no intervention | 149 dust control intervention + training/ 162 training/ and 113 controls | exposure reduction and education | 1. Significant decrease in FeNO (p = 0.24) is associated with reduction in exposure if baseline FeNO > 25 ppb |
2. Workers with work-related ocular-nasal symptoms at baseline, had a significant decline in FeNO (≥ 10 ppb) in the intervention group. | |||||
Dressel H. et al., 2007 [32] | Cow dander and storage mites | intervention vs no intervention | 81 exposed/24 controls | education | 1. In the intervention group, FeNO decreased significantly (p < 0.05) |
2. In the intervention group, the decrease was higher in subjects with baseline elevated FeNO > 35 ppb (p < 0.01). 3. Spirometric values did not changed significantly in the two groups. | |||||
Dressel H. et al., 2009 [33] | Cow dander and storage mites | intervention vs no intervention | 43 exposed/ 15 controls | education | 1. The decrease in FeNO was maintained 1 year after the intervention(p = .001); in the control group there was a slight but not statistically significant increase in FeNO. |
2. Spirometric values did not changed significantly in both groups. |