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Table 2 Effect sizes of occupational exposure to develop HOA among different subgroups

From: Influence of physically demanding occupations on the development of osteoarthritis of the hip: a systematic review

Occupation

Subgroup

Number of studies

RR (95%-CI)

Hetero-

geneity (I2)

Subgroup differences

Agriculture and forestry

All studies

12

2.81 (2.22–3.55)a

90%

 

Disability pension due to HOA

3

3.96 (1.36–11.51)a

73%

p = 0.72

THR, no information on disability pension reported

3

2.41 (1.45–4.00)a

91%

Diagnosis, but no THR

6

2.60 (1.81–3.72)a

92%

Cohort studies

6

2.67 (2.01–3.55)a

95%

p = 0.51

Case–control studies

6

3.24 (1.96–5.37)a

61%

Construction worker

All studies

9

1.64 (1.28–2.09)

49%

 

Disability pension due to HOA

3

2.79 (1.36–5.72)

59%

p = 0.12

THR, no information on disability pension reported

2

1.31 (1.02–1.70)

38%

Diagnosis, but no THR

4

1.60 (1.36–1.87)

0%

Cohort studies

5

1.55 (1.34–1.78)

0%

p = 0.54

Case–control studies

4

1.92 (0.97–3.77)a

73%

Driving vehicles with whole body vibration

All studies

8

1.52 (1.11–2.08)a

72%

 

Disability pension due to HOA

2

2.35 (0.85–6.49)a

67%

p = 0.18

THR, no information on disability pension reported

3

1.12 (0.78–1.59)

51%

Diagnosis, but no THR

3

1.68 (1.15–2.45)

50%

Cohort studies

5

1.42 (0.92–2.21)a

79%

p = 0.32

Case–control studies

3

1.87 (1.39–2.52)

3%

Metal work

All studies

6

1.54 (1.21–1.97)

37%

 

Disability pension due to HOA

3

1.83 (1.15–2.90)

0%

p = 0.28

THR, no information on disability pension reported

1

1.10 (0.67–1.80)

-

Diagnosis, but no THR

2

1.72 (1.10–2.68)

22%

Cohort studies

4

1.42 (1.08–1.87)

0%

p = 0.21

Case–Control studies

2

2.09 (1.23–3.56)

0%

Sales

All studies

5

1.50 (1.01–2.24)b

38%

 

Comparable physical demanding occupations

4

1.50 (0.82–2.75)

51%

p = 0.83

Heterogeneous physical demanding occupations

1

1.39 (0.95–2.03)

-

Disability pension due to HOA

1

2.35 (1.19–4.66)

-

 p = 0.33

THR, no information on disability pension reported

2

1.77 (1.00–3.16)

0%

Diagnosis, but no THR

2

0.96 (0.37–2.51)c

65%

Cohort studies

2

1.67 (1.02–2.72)

42%

p = 0.51

Case–Control Studies

3

1.21 (0.54–2.70)

56%

Gastronomy

All studies

4

1.44 (0.78–2.66)c

63%

 

Cohort studies

3

1.70 (0.92–3.15)a

63%

p = 0.13

Case–Control Studies

1

0.60 (0.18–2.02)

-

Storage and transportation

All studies

3

2.09 (0.88–4.96)

0%

 

Cohort study

1

0.92 (0.12–6.99)

-

p = 0.51

Case–Control-Studies

2

2.50 (0.96–6.52)

0%

Food production

All studies

4

2.13 (1.53–2.95)b

0%

 

Comparable physical demanding occupations

3

2.22 (1.39–3.54)

0%

P = 1.00

Less physical demanding occupations in construction

1

2.04 (1.28–3.24)

-

Cohort study

2

2.10 (1.48–2.96)b

0%

p = 0.84

Case–Control-Studies

2

2.40 (0.64–8.97)

37%

Health care

All studies (only cohort studies)

3

1.21 (0.51–2.88)c

88%

 

Unskilled or basic level labours

All studies

3

1.89 (1.29–2.77)

34%

 

Cohort studies

2

2.15 (1.31–3.54)

46%

p = 0.28

Case–Control Studies

1

1.4 (0.77–2.56)

-

  1. CI confidence interval, HOA hip osteoarthritis, RR relative risk, THR total hip replacement
  2. Pooling not useful due to substantial heterogeneity between results of individual studies (a), clinical heterogeneity in severity of physical demanding occupations (b) or both (c)