Table 12 Conclusions on carcinogenic activity of 2-year inhalation studies of male and female F344/N rats and B6C3F1 mice exposed to nickel subsulphide, nickel oxide and nickel sulphate hexahydrate [30–32]; and Wistar rats exposed to nickel metal powder [35]
| Evidence of carcinogenic activity | |||||
|---|---|---|---|---|---|
| F344/N rats | B6C3F 1 mice | ||||
| Nickel compound | Ni Solubility | Male | Female | Male | Female |
| Nickel subsulfide | Insoluble | Clear evidence | Clear evidence | No evidence | No evidence |
| Nickel oxide | Insoluble | Some evidence | Some evidence | No evidence | Equivocal evidence |
| Nickel sulfate hexahydrate | Soluble | No evidence | No evidence | No evidence | No evidence |
| Wistar rats | |||||
| Nickel metal powder | Insoluble | No evidence | No evidence | - | - |
