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Table 12 Conclusions on carcinogenic activity of 2-year inhalation studies of male and female F344/N rats and B6C3F1 mice exposed to nickel subsulphide, nickel oxide and nickel sulphate hexahydrate [3032]; and Wistar rats exposed to nickel metal powder [35]

From: New views on the hypothesis of respiratory cancer risk from soluble nickel exposure; and reconsideration of this risk's historical sources in nickel refineries

   Evidence of carcinogenic activity
   F344/N rats B6C3F 1 mice
Nickel compound Ni Solubility Male Female Male Female
Nickel subsulfide Insoluble Clear evidence Clear evidence No evidence No evidence
Nickel oxide Insoluble Some evidence Some evidence No evidence Equivocal evidence
Nickel sulfate hexahydrate Soluble No evidence No evidence No evidence No evidence
   Wistar rats   
Nickel metal powder Insoluble No evidence No evidence - -