Leupeptin reduces impulse noise induced hearing loss

Table 2 ABR threshold (in dB pe SPL) before and 8 days after M16 rifle impulse noise exposure and the resulting threshold shift with application of either saline or leupeptin to the middle ear for 4 consecutive days.

Animal	Initial Threshold		Final Threshold*		Threshold Shift
	Saline	Leupeptin	Saline	Leupeptin	Saline	Leupeptin
1	45	50	55	50	10	0
2	50	50	105	120	55	70
3	45	50	115	85	70	35
4	45	50	60	45	15	-5
5	50	50	95	75	45	25
6	50	50	120*	80	70	30
7	70	50	120*	80	50	30
8	55	60	90	90	35	30
Mean ± SD	51.3 ± 7.8	51.3 ± 3.3	95.0 ± 23.9	78.1 ± 21.9	43.7 ± 21.1	26.9 ± 21.4

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