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Table 1 ABR thresholds (± SD) in the different groups at baseline and 7 and 21 days later.

From: Combined effects of salicylic acid and furosemide and noise on hearing

Experimental group

Set A (SA 350 mg/kg, F 100 mg/kg)

Set B (SA 300 mg/kg, F 50 mg/kg)

 

n

Threshold baseline (dB)

Threshold day 7 (dB)

Threshold shift

n

Threshold baseline (dB)

Threshold

day 7 (dB)

Threshold shift

Threshold day 21 (dB)

Threshold shift

I: Saline + noise exposure

7

52.1 ± 10.4

82.1 ± 17.5

34.3 ± 17.7

4

62.5 ± 2.9

90.0 ± 16.8

27.5 ± 18.9

91.3 ± 18.9

28.8 ± 19.3

II: SA only + noise exposure

5

48.0 ± 9.0

73.0 ± 18.2

25.0 ± 17.0

6

59.2 ± 5.8

78.3 ± 16.0

19.2 ± 13.9

76.7 ± 15.4

15.8 ± 10.2

III: F only + noise exposure

8

55.0 ± 7.1

76.9 ± 17.1

21.9 ± 13.4

6

59.2 ± 5.8

80.0 ± 8.4

20.8 ± 7.4

81.7 ± 11.3

22.5 ± 16.0

IV: SA + F + noise exposure

8

51.9 ± 12.2

88.8 ± 14.8

38.8 * ± 19.0

6

59.2 ± 5.8

87.5 ± 15.7

28.3 * ± 11.7

90.0 ± 16.1

30.0 * ± 13.4

V: SA + F no noise exposure

3

50.0 ± 8.7

58.3 ± 5.8

6.7 ± 5.8

6

60.8 ± 3.8

68.3 ± 15.4

10.0 ± 12.3

63.3 ± 5.8

2.5 ± 4.2

  1. Different drug doses were administered to the two sets (A and B) of mice.
  2. * There is no significant difference in threshold shift between the mice receiving all 3 agents (group IV; SA + Furosemide + noise) and those receiving saline before noise (group I). (P > 0.6)
  3. SA: salicylic acid, F: furosemide, dB: decibel, n: number of mice