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Table 4 Strength of evidence for agents, professions and work-site according to the modified RCGP three-star system [88]

From: Bronchial asthma and COPD due to irritants in the workplace - an evidence-based approach

Evidence level (modified RCGP three-star grading) Number of agents/work-sites or professions Agents, work-site or profession [Synonym] (CAS)
*** 0 -
** 17 Benzene-1, 2, 4-tricarboxylic acid-1,2-anhydride [trimellitic anhydride] (552-30-7); chlorine ( 7782-50-5); cobalt (7440-48-4); various isocyanates, isocyanurate (HDI, MDI, TDI), diphenylmethane diisocyanate [MDI] (5873-54-1), toluene diisocyanate, TDI 2,4 (584-84-9), TDI 2,6: (91-08-7); platinum salts (7440-06-4); cement ; environmental tobacco smoke; grain ; welding fumes; construction work (dust, agent not specified); farming, animals (pig, beef/veal, dairy, poultry); swine confinement; World Trade Center disaster 2001
*[*] 12 Ceramic production; Phthalic anhydride (85-44-9); glutaraldehyde [glutaral] (11-30-8); sulfur dioxide (7446-09-5); cotton (dust, raw) CNT 750; potroom aluminum smelting; farming (various); foundry; smoke (fires, pyrolysis products); pesticides (not specified); cleaning agents (not specified); health care workers
* 39 Acetic acid (64-19-7); sulfuric acid (7664-93-9); metacrylates, loctide® (53858-53-0); aluminum salts [aluminum fluoride] (7724-18-1); aluminum sulfate: (10043-01-3); ammonia (7664-41-7); various anhydrides; tetrachlorophthalic anhydride (117-08-8); azobisformamide (123-77-3); cadmium (fumes) (7440-43-9); carbon black dust (1333-86-4); ethylenediamine (107-15-3); formaldehyde (gas, dust) (50-00-0); hexamethylenetetramine ( 100-97-0); methyl isocyanate [MIC] (624-83-9); naphthylene diisocyanate (3173-72-6); polymethylene polyphenyl isocyanate (9016-87-9); N-methylmorpholine (09-02-4); ozone (gassings) (10028-15-6); paraquat (4685-14-7); diammonium peroxodisulfate (7727-54-0); phenylglycine acid chloride ( 39478-47-2); piperazine dihydrochloride (142-64-3); polyvinyl chloride (fume) (9002-86-2); rosin core solder; thermal decomposition (8050-09-7); vanadium (7440-62-2) + divanadium pentoxide (1314-62-1); cleaning agents (not specified); green coffee ; diesel exhaust; endotoxin; oil (spill); paint (fumes); pesticides (not specified); reactive dyes; refractory ceramic fibers [RCF]; smoke (fires, pyrolysis products; oil fire and dust storm); soldering flux; solvents (not specified); health care workers; poultry confinement; slaughtery house; metallurgical industry workers
[*] 3 Nitrogen chloride ( 10025-85-1); polyamines, aliphatic; potassium persulfate (7727-21-1) and ammonium peroxydisufate (7727-54-0); grain rice
(*) 29 Acids not specified; hydrochloric acids (7647-01-0); alkyl cyanoacrylates; 3-amino-5-mercapto-1,2,4-triazole l(16691-43-3); aziridine, polyfunctional (64265-57-2); chloramine T (powder dust) (7080-50-4); chromate (not specified); 3-(diamino-amino)propylamine (109-55-7); dichlorodiethyl sulfide (505-60-2); 2-diethylaminoethanol (100-37-8); diinitrogen tetraoxide (10544-72-6); hexamethylene diisocyanate [HDI], plus isodurane diisocyanate (822-06-0); HDI biuret plus (4035-89-6); nickel sulphate anhydrous (7786-81-4); hexahydrate (10101-97-0); paraphenylenediamine (106-50-3); persulfate (not specified); polypropylene, heated to 250 °C (9003-07-0); potassium dichromate (7778-50-9); potassium aluminum tetrafluoride (14484-69-6); sodium iso-nonanoyl oxybenzene sulphonate [SINOS] (123354-92-7); sodium metabisulfite (7681-57-4); styrene monomer (100-42-5); chlorofluorocarbons (degradation products); hairdressing chemicals; lubricants (not specified); paper dust A111; aliphatic polyamines; polyester; powder paints; smoke (biomass, indoor)
- 93 Acids various; dodecanedioic (693-23-2-1); hydrofluoric acids (7664-39-3); cyanoacrylate glue; methyl 2-cyanoacrylate (137-05-3); methylmethacrylate (80-62-6); 2-aminoethanol (141-43-5); amino-ethyl-ethanolamine (111-41-1); ammonium chloride (triple salt) (12125-02-9); ammonium thioglycolate (5421-46-5); amprolium hydrochloride (137-88-2); dioctyl phthalate (117-81-7); hexahydrophthalic anhydrides (37226-48-5); himic anhydrides (2746-19-2); maleic anhydrides (108-31-6); methyltetrahydrophthalic anhydrides (26590-20-9); pyromellitic dianhydride (89-32-7); benzalkonium chloride (fumes) (8001-54-5); 1, 2-benzisothiazoline-3-one (fumes) (2634-33-5); bisulfite, SO2:(7446-09-5); hydrobromic acid bromine; bromochlorodifluoromethane [halon 1211] (353-59-3); bromotrifluoromethane [halon 1301](75-63-8); calcium carbonate [chalk powder]; calcium oxide (1305-78-8); captafol (2425-06-1); chlorhexidine (55-56-1); aliphatic + cycloaliphatic diamine, (hardener) (2855-13-2) [isophorone diamine]; diazonium tetrafluoroborate (14239-22-6); dichlorvos [organophosphate] (62-73-7); diethanolamine (111-42-2); 2-dimethylaminoethanol [dimethyl ethanolamine] (108-01-0); ethylene oxide (75-21-8); freon-22; hexachlorophene (70-30-4); hydrazine (302-01-2); iridium salt; isocyanate prepolymers; 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate (4098-71-9); triglycidil isocyanurate (2451-62-1); triphenylmethane triisocyanate; isothiazolinone (55965-84-9); lauryl dimethyl benzyl ammonium chloride (139-07-1); metam sodium (144-54-7); methylmercaptan (74-93-1); monoethanolamine (141-43-5); ninhydrin (485-47-2); palladium (7440-05-3); ammonium persulfate; alcalic persulfate; sodium persulfate (7775-27-1); dipotassium peroxo-peroxodisulfate (7727-21-1); phosgene (75-44-5); polyethylene (9002-88-4); polymethyl-methacrylate (9011-14-7); sodium azide (powder dust) (26628-22-8); sulfathiazole (2-14-0); terpene (3-carene) (3466-78-9); tetrahydrothiophene (110-01-0); tetrachloroisophthalonitrile (fungicide); tetramethrin (7696-12-0); tributyl tin oxide; triethanolamine (102-71-6); tungsten carbide (11130-73-7); turpentine (8006-64-2); tylosin tartrate; uranium hexafluoride (7783-81-5); urea (fume) (57-13-6); urea formaldehyde foam (64869-57-4); phenol-formaldehyde resin (9003-35-4); zinc (fume) (7440-66-6); zinc chloride (fume) (7646-85-7); acid fluxes; acrylic acid; airbag content; bleaching agent (fumes); chlorofluorocarbons (degradation products); detergents; cutting oil; ECG ink; floor sealant (aromatic hydrocarbons); fumigating agent; furan-based binder; metal coating remover (coating removing chemical); metal oxide (fume); metal working fluids; perfume agents (research lab); pyrazolone; spray paint; tall oil; tear gas
  1. CAS = Chemical abstracts service.
  2. RCGP = Royal College of General Practitioners.