Diesel engine exhaust and lung cancer risks – evaluation of the meta-analysis by Vermeulen et al. 2014

Table 10 Linear regression with fixed effects for log RR with weights proportional to the inverse of the respective variance, with adjustment for studies

log RR	Coef.	Std. Err.	t	P	95 % CI
Dose	0.00106	0.00020	5.35	0.002 (<0.001)	0.00057 (0.00067	0.00154 0.00144)
ΔConst1	0.249	0.080	3.11	0.021	0.052	0.445
ΔConst2	−0.035	0.126	−0.28	0.79	−0.343	0.272
Constant	−0.059	0.079	−0.74	0.49	−0.252	0.135
Crump et al. [14], REC4
Dose	0.00053	0.00021	2.49	0.047 (0.013)	0.00001 (0.00011	0.00105 0.00094)
ΔConst1	0.163	0.095	1.71	0.14	−0.070	0.396
ΔConst2	−0.167	0.169	−0.98	0.36	−0.581	0.248
Constant	0.091	0.091	1.01	0.35	−0.130	0.313
Crump et al. [14], REC6
Dose	0.00054	0.00017	3.12	0.021 (0.0018)	0.00012 (0.00020	0.00096 0.00087)
ΔConst1	0.164	0.069	2.40	0.054	−0.003	0.332
ΔConst2	0.041	0.113	−0.37	0.73	−0.319	0.236
Constant	0.088	0.068	1.30	0.24	−0.079	0.255

Coefficient (Coef.) of the cumulative exposure (Dose) to DEE in μg/m³-years and absolute term (Constant) with standard deviation (Std.Err.); t-test statistic for the coefficient with the corresponding P-value and a 95 % confidence interval for the coefficient, 95 % CI. The figures in parentheses are the results when using the standard normal distribution. Silverman et al. [4] was incorporated as used by Vermeulen et al. [1], and in accordance with the re-analysis by Crump et al. [14] with adjustment for radon exposure (REC4, REC6, cf. Table 3)
Constant: Steenland et al. [2] (reference study)
ΔConst1: Garshick et al. [3] - Steenland et al. [2]
ΔConst2: Silverman et al. [4] - Steenland et al. [2]

ISSN: 1745-6673