Occupation and prostate Cancer risk: results from the epidemiological study of prostate cancer (EPICAP)

Bijoux, Wendy; Cordina-Duverger, Emilie; Balbolia, Soumaya; Lamy, Pierre-Jean; Rebillard, Xavier; Tretarre, Brigitte; Cenee, Sylvie; Menegaux, Florence

doi:10.1186/s12995-022-00346-2

Journal of Occupational Medicine and Toxicology

Table 3 Associations between selected occupations⁺ and prostate cancer aggressiveness (N = 1680)

From: Occupation and prostate Cancer risk: results from the epidemiological study of prostate cancer (EPICAP)

ISCO^* Code (1 to 3 digits): Description	CA^**	Never	Ever employed		< 10 years employed		≥ 10 years employed
ISCO^* Code (1 to 3 digits): Description	CA^**	n^***	n	OR [95% CI]^****	n	OR [95% CI]	n	OR [95% CI]
*0/1: PROFESSIONAL, TECHNICAL AND RELATED WORKERS*	NA^† A^†† C^†††	401 106 571	222 76 304	0.96 [0.73; 1.25] 1.63 [1.11; 2.42]	64 22 102	0.89 [0.61; 1.28] 1.36 [0.79; 2.32]	158 54 202	1.00 [0.73; 1.35] 1.83 [1.17; 2.86]
0–2: Architects, Engineers	NA A C	595 177 836	28 5 39	0.89 [0.52; 1.52] 0.68 [0.25; 1.80]	8 1 21	0.48 [0.20; 1.12] 0.24 [0.03; 1.87]	20 4 18	1.38 [0.69; 2.75] 1.18 [0.38; 3.66]
0–3: Surveyors, Draughtsmen and Related technicians	NA A C	565 158 804	58 24 71	1.23 [0.85; 1.80] 1.68 [1.00; 2.81]	27 10 41	0.99 [0.59; 1.67] 1.35 [0.65; 2.79]	31 14 30	1.56 [0.92; 2.65] 2.11 [1.06; 4.21]
0–6: Medical, Dental and Veterinary workers	NA A C	609 177 869	14 5 6	2.90 [1.07; 7.89] 4.63 [1.33; 16.15]	0 1 1	- 2.01 [0.10; 39.56]	14 4 5	3.53 [1.22; 10.22] 5.01 [1.27; 19.77]
0–61: Medical Doctors	NA A C	614 180 872	9 2 3	3.94 [1.03; 15.04] 4.16 [0.65; 26.55]	0 0 0	- -	9 2 3	3.94 [1.03; 15.04] 4.16 [0.65; 26.55]
*2: ADMINISTRATIVE AND MANAGERIAL WORKERS*	NA A C	507 154 760	116 28 115	1.51 [1.11; 2.06] 1.29 [0.80; 2.06]	21 8 35	0.83 [0.46; 1.51] 1.28 [0.57; 2.91]	95 20 80	1.82 [1.29; 2.57] 1.30 [0.75; 2.23]
2–0: Legislative Officials and Government Administrators	NA A C	604 180 865	19 2 10	2.52 [1.13; 5.62] 1.06 [0.22; 5.03]	8 1 5	1.83 [0.58; 5.79] 0.84 [0.10; 7.49]	11 1 5	3.30 [1.10; 9.84] 1.29 [0.15; 11.41]
2–02: Government Administrators	NA A C	606 180 867	17 2 8	3.00 [1.25; 7.19] 1.38 [0.28; 6.74]	6 1 3	2.55 [0.62; 10.52] 1.42 [0.14; 14.23]	11 1 5	3.30 [1.11; 9.85] 1.30 [0.15; 11.49]
2–1: Managers	NA A C	520 155 767	103 27 108	1.39 [1.02; 1.91] 1.30 [0.81; 2.10]	20 8 34	0.79 [0.43; 1.45] 1.31 [0.58; 2.96]	83 19 74	1.68 [1.18; 2.41] 1.31 [0.75; 2.28]
2–11: General Managers	NA A C	586 172 843	37 10 32	2.01 [1.19; 3.38] 1.82 [0.86; 3.89]	10 4 13	1.31 [0.53; 3.24] 2.12 [0.65; 6.95]	27 6 19	2.45 [1.30; 4.63] 1.70 [0.65; 4.45]
*3: CLERICAL AND RELATED WORKERS*	NA A C	439 132 611	184 50 264	0.94 [0.74; 1.20] 0.82 [0.56; 1.19]	81 20 100	1.08 [0.77; 1.51] 0.84 [0.49; 1.44]	103 30 64	0.86 [0.64; 1.15] 0.81 [0.52; 1.26]
*4: SALES WORKERS*	NA A C	465 144 693	158 38 182	1.30 [1.00; 1.68] 1.01 [0.67; 1.51]	72 23 89	1.13 [0.80; 1.61] 1.24 [0.75; 2.06]	86 15 93	1.47 [1.05; 2.05] 0.78 [0.43; 1.40]
4–0: Managers (Wholesale and Retail Trade)	NA A C	607 177 864	16 5 11	1.86 [0.83; 4.20] 1.95 [0.65; 5.80]	7 4 3	2.12 [0.50; 8.98] 5.66 [1.19; 26.83]	9 1 8	1.86 [0.70; 4.96] 0.54 [0.07; 4.43]
*5: SERVICE WORKERS*	NA A C	516 153 700	107 29 175	0.81 [0.61; 1.07] 0.72 [0.46; 1.13]	43 12 94	0.55 [0.37; 0.83] 0.55 [0.29; 1.03]	64 17 81	1.12 [0.78; 1.62] 0.94 [0.53; 1.65]
5–5: Building Caretakers, Charworkers, Cleaners and Related Workers	NA A C	613 180 849	10 2 26	0.47 [0.22; 1.02] 0.35 [0.08; 1.49]	8 2 19	0.50 [0.21; 1.23] 0.49 [0.11; 2.16]	2 0 7	0.38 [0.07; 2.03] -
5–8: Protective Service Workers	NA A C	579 171 805	44 11 70	0.84 [0.56; 1.27] 0.70 [0.36; 1.37]	16 4 34	0.58 [0.31; 1.10] 0.52 [0.18; 1.52]	28 7 36	1.09 [0.64; 1.84] 0.87 [0.38; 2.03]
*6: AGRICULTURAL ANIMAL HUSBANDRY AND FORESTRY WORKERS, FISHERMEN AND HUNTERS*	NA A C	547 150 762	76 32 113	0.89 [0.64; 1.24] 1.30 [0.83; 2.05]	35 13 54	0.85 [0.53; 1.35] 1.15 [0.60; 2.20]	41 19 59	0.93 [0.60; 1.44] 1.44 [0.81; 2.57]
6–4: Fishermen, Hunters and Related Workers	NA A C	614 177 867	9 5 8	1.53 [0.57; 4.11] 3.16 [1.00; 10.05]	2 0 2	1.66 [0.22; 12.50] -	7 5 6	1.54 [0.50; 4.74] 4.58 [1.33; 15.78]
6–41: Fishermen	NA A C	619 178 870	4 4 5	1.13 [0.29; 4.39] 4.01 [1.02; 15.69]	1 0 1	1.84 [0.11; 30.43] -	3 4 4	1.01 [0.22; 4.75] 5.10 [1.20; 21.61]
*7/8/9: PRODUCTION AND RELATED WORKERS, TRANSPORT EQUIPMENT OPERATORS AND LABOURERS*	NA A C	305 86 364	318 96 511	0.76 [0.59; 0.97] 0.73 [0.50; 1.06]	107 26 160	0.81 [0.59; 1.12] 0.63 [0.38; 1.04]	211 70 351	0.72 [0.55; 0.95] 0.79 [0.52; 1.18]
7–0: Production Supervisors and General Foremen	NA A C	570 166 821	53 16 54	1.60 [1.06; 2.41] 1.60 [0.88; 2.89]	22 5 24	1.43 [0.77; 2.65] 1.11 [0.41; 3.02]	31 11 30	1.73 [1.02; 2.94] 1.98 [0.96; 4.09]
7–4: Chemical Processers and Related Workers	NA A C	622 182 866	1 0 9	0.14 [0.02; 1.18] -	0 0 5	- -	1 0 4	0.37 [0.04; 3.57] -
7–7: Food and Beverage Processers	NA A C	600 176 828	23 6 47	0.62 [0.36; 1.07] 0.51 [0.21; 1.23]	11 5 25	0.54 [0.25; 1.16] 0.76 [0.28; 2.08]	12 1 22	0.72 [0.34; 1.51] 0.19 [0.03; 1.46]
8–1: Cabinetmakers and Related Woodworkers	NA A C	611 180 870	12 2 5	3.53 [1.20; 10.39 1.62 [0.30; 8.65]	8 1 2	4.97 [1.01; 24.42] 1.84 [0.16; 21.03]	4 1 3	2.46 [0.53; 11.30] 1.52 [0.15; 15.20]
8–3: Blacksmiths, Toolmakers and Machine Tool Operators	NA A C	599 173 820	24 9 55	0.67 [0.40; 1.12] 0.83 [0.40; 1.74]	12 4 34	0.53 [0.27; 1.05] 0.57 [0.20; 1.66]	12 5 21	0.90 [0.43; 1.90] 1.29 [0.47; 3.55]
8–39: Blacksmiths, Toolmakers and Machine-Tool Operators Not Elsewhere Classified	NA A C	617 178 857	6 4 18	0.52 [0.20; 1.37] 1.19 [0.39; 3.66]	1 0 14	0.12 [0.02; 0.92] -	5 4 4	1.83 [0.47; 7.19] 5.36 [1.28; 22.45]
9–7: Material Handling and Related Equipment Operators, Dockers and Freight Handlers	NA A C	585 162 794	38 20 81	0.62 [0.41; 0.95] 1.24 [0.72; 2.15]	31 17 58	0.71 [0.44; 1.15] 1.51 [0.83; 2.75]	7 3 23	0.40 [0.17; 0.97] 0.61 [0.18; 2.09]
9–8: Transport Equipment Operators	NA A C	558 159 752	65 23 123	0.71 [0.50; 1.00] 0.85 [0.52; 1.40]	30 7 63	0.65 [0.41; 1.05] 0.51 [0.22; 1.14]	35 16 60	0.76 [0.48; 1.21] 1.22 [0.67; 2.24]
9–85: Motor-Vehicle Drivers	NA A C	571 163 780	52 19 95	0.74 [0.50; 1.08] 0.93 [0.54; 1.60]	25 6 48	0.68 [0.40; 1.15] 0.57 [0.24; 1.39]	27 13 47	0.80 [0.48; 1.34] 1.31 [0.67; 2.55]
*MEMBERS OF THE ARMED FORCES*	NA A C	612 177 857	11 5 18	0.87 [0.40; 1.90] 1.36 [0.49; 3.77]	8 2 15	0.76 [0.31; 1.84] 0.64 [0.14; 2.88]	3 3 3	1.46 [0.29; 7.48] 5.14 [0.99; 26.71]

Abbreviations: ⁺occupations (exercised by 10 subjects or more) with at least one statistically significant association for ever employment or duration of employment; ^*ISCO: international standard classification of occupations (version of 1968); ^**CA: cancer aggressiveness; ^***n: number of participants in each group; ^****Odds ratio adjusted for age (age of reference (60–64 years)), ethnic origin, first-degree family history of this cancer, educational level, intensity of physical activity, waist circumference, marital status; ^†NA: non-aggressive cancer cases (Gleason score ≥ 7 (3 + 4)); ^††A: aggressive cancer cases (Gleason score ≤ 7 (4 + 3)); ^†††C: controls; ^††††Other health professionals: Nurses, Midwives, Optometrists and opticians, Physiotherapists and occupational therapists, Medical radiology technicians

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