Open Access

A case of isocyanate-induced asthma possibly complicated by food allergy after peanut consumption: a case report

  • Ervin Ç Mingomataj1Email author,
  • Enkelejda Gjata2,
  • Fatmira Xhixha3 and
  • Entela Hyso4
Journal of Occupational Medicine and Toxicology20083:29

https://doi.org/10.1186/1745-6673-3-29

Received: 30 January 2006

Accepted: 26 November 2008

Published: 26 November 2008

Abstract

Background

Isocyanates are extensively used in the manufacture of polyurethane foams, plastics, coatings or adhesives. They are a major cause of occupational asthma in a proportion of exposed workers. Recent findings in animal models have demonstrated that isocyanate-induced asthma does not always represent an IgE-mediated sensitization, but still a mixed profile of CD4+ Th1 and TH2, as well as a CD8+ immune response. Despite immunologic similarities between this pathology and IgE-mediated food allergies, this co-morbidity is rarely reported.

Case presentation

A 50-year old man employed as vehicle body painter, for 8 years complained about breathlessness, wheezing, sneezing, nasal obstruction and excessive production of mucus during the use of DuPont Refinish Centari Tintings – an acrylic enamel tint. Symptoms occurred 15–20 minutes after workplace exposure and usually persisted until evening, or at times, up to two consecutive days. The above mentioned symptoms were associated with a decrease of lung functions parameters. The use of inhaled adrenergic bronchio-dilatators and steroids relived the symptoms.

In addition, three years ago he developed an anaphylactic reaction due to peanut consumption, experiencing urticaria, angioedema and airway obstruction. He was successfully treated in the hospital. Later, the subject exhibited labial itching, as well as orbital and perioral angioedema, 20 minutes after stationary performance of challenge test with peanuts.

Evaluating the reported data, this process might be developed rather due to induction of a TH2 profile, because in both cases have occurred IgE-mediated symptoms. A less plausible mechanism could be the presence of isocyanates in peanuts due to a probable contamination by pesticides resulting in an allergic reaction after "consumption" of di-isocyanate as long as the isocyanate contamination of peanuts has not been proven.

Conclusion

Despite the lack of relevant laboratory findings, this might be the first case of isocyanate-induced occupational asthma described in a patient who developed peanut allergy symptoms later in his life. However, in order to take further suitable precautions, further studies are necessary to elucidate the questions posed in this report.

Background

Isocyanates, widely used in the manufacture of polyurethane foams, plastics, coatings, or adhesives, and are known to cause the most common type of occupational asthma in a number of exposed workers [14]. Additionally, some residents living nearby fiber processing and polyurethane foam manufacturing facilities become sensitized to toluene di-isiocyanate (TDI) [5].

With respect to pathogenesis, recent findings especially in animal models demonstrated that isocyanate-induced asthma does not always represent an IgE-mediated sensitization, but still a mixed profile of CD4+ Th1 and TH2, as well as CD8+ immune response [2, 4, 610]. Also a combined IL-4/IL-13 depletion in a murine model effectively prevented almost all asthma pathologic symptoms [4]. Furthermore, Herrick et al. demonstrated that eosinophilic inflammatory processes in the airways were mediated by TH2 cytokines and not by IFNγ [7, 8].

This pathology has an important clinical relevance, because asthmatic symptoms are developed in 5–15% of exposed workers and these symptoms may persist even after complete isocyanate avoidance, perhaps due to metalloproteinase MMP-9 overproduction and consequent induction of airway inflammation and remodeling [9, 11, 12]. Apart from the inhalation route of exposure, many experimental findings in animals have demonstrated the potential role of dermal contact after isocyanate exposure regarding the initial response and subsequent development of occupational asthma, whereas the use of latex gloves did not prevent the isocyanate sensitization among exposed workers [9, 1316].

Despite some immunologic similarities between this pathology and IgE-mediated food allergies, this co-morbidity is rarely reported. In effect, peanut allergy occurs generally in childhood [17]. Because of these facts, the description of a case of isocyanate-induced occupational asthma in a patient who developed symptoms of peanut allergy later in his life could be of great interest.

Case presentation

Our case

A 50-year old man, a former smoker, employed as vehicle body painter 25 years ago, used to work with an acrylic enamel tint – DuPont Refinish Centari Tintings. 17 years later, he began to exhibit urticaria and facial angioedema after work exposure. These symptoms were resolved after treatment with antihistamines. The last 8 years he experienced also cough, breathlessness, wheezing, sneezing, nasal obstruction and excessive production of mucus. The symptoms occurred 15–20 minutes after exposure to acrylic enamel tint at the workplace and persisted usually until the evening, or at times, up to two consecutive days. The use of inhaled adrenergic bronchio-dilatators and steroids relived the symptoms within two hours. In fact, he irregularly used to inhale budesonide in case of clinical deteriorations. He had used an oronasal mask to avoid tint for four years. The subject experienced different respiratory obstructive symptoms such as nasal obstruction and excessive production of mucus, sneezing, as well as dispnoea and chest tightness, if he discontinued the using of the face mask at workplace.

Spirometry showed normal ventilatory function in the non-working days. A significant reduction in forced expiratory volume at first second (FEV1) (50%), functional vital capacity (FVC) (67%) and peak expiratory flow (PEF) (75%) was observed after work exposure. The above mentioned respiratory functional parameters were normalized after the use of inhalant bronchio-dilatators and steroids. Consequently, within two hours the symptoms were resolved. Skin prick tests with common aeroallergens were negative. Blood test and radiological examinations were within normal limits. There was no familial history of atopy.

In addition, three years ago he developed an anaphylactic reaction due to peanut consumption. The patient manifested classical symptoms of anaphylaxis as urticaria, angioedema and dispnoea. He showed a marked clinical improvement only after four hours of treatment in hospital. Some months later, the patient underwent the oral challenge test with peanuts and 20 minutes later, he developed labial itching, as well as orbital and perioral angioedema. Afterwards, he followed a strict peanut elimination diet. All these findings confirm the diagnoses of occupational asthma and rhinitis due to isocyanates and peanut anaphylactic reaction.

Discussion

TDI and diphenyl-methane di-isocyanate (DMI), used as drying accelerator of Centari tint, are widely known as respiratory irritators [14]. Isocyanates are a group of aromatic and aliphatic compounds of low molecules weight containing the group -N = C = O [9]. The ability to react with acrylic polyols and therefore to form the coating makes this compound a drying accelerator for paints and varnishes [1]. On the other hand, many reports point out that high concentrations of these compounds in the air, especially of TDI, irritate and sensitize the airways of exposed workers [4, 9, 11, 12, 16].

The most plausible immune mechanism involved in the sensitization to di-isocyanates is the TH2 profile induction, but simultaneous induction of TH1 and CD8 responses are also reported [2, 4, 6, 7, 9, 15]. Recent studies in animal models have shown that sensitization can occur through subchronic inhalation of di-isocyanate at levels as low as 20 ppb as well as through dermal exposure [2, 7, 10, 1416, 18]. Unfortunately, in Albania there is no reliable authority to control the environmental conditions of workplaces, especially in small private establishments. In this respect, rigorous preventive measures are needed [1, 3].

The association of isocyanate-induced occupational asthma and anaphylaxis to peanuts consumption has not been described previously. Such complication of isocyanate-induced occupational asthma by food allergy is reported at least in two cases and the implicated foods were the plants of the mustard family [19, 20]. The suggested phys-pathological mechanism of these cases was the cross-reactivity, as isothiocyanates are found in mustard spice [19]. As long as such compounds are not seen in peanuts, the induction of anaphylaxis due to peanut consumption as a consequence of prior isocyanate-induced occupational sensitization was not demonstrated.

The association of both pathologies could be explained with induction of TH2 immune response rather than with induction of TH1 one. This is supported by typical clinical findings such as the occurrence of IgE-mediated symptoms following peanut consumption in a subject previously diagnosed with an isocyanate-induced asthma, even if in our case there was no laboratory evidence (because of objective reasons) [2, 4, 69].

On the other hand, a less plausible mechanism could be the presence of isocyanates in peanuts due to a probable contamination by pesticides and therefore, an allergic reaction was induced after the di-isocyanates "consumption". In this respect, isocyanates such as methylisocyanate, used as intermediates in the synthesis of carbamate pesticides or di-isocyanates, are highly reactive compounds that spontaneously bind to biological macromolecules [9, 21]. Because the isocyanate peanuts contamination has not been proven, very limited data support this hypothesis.

Conclusion

The lack of relevant laboratory findings could be a limitation for this report. Nevertheless, this case description could be of interest, because it is possibly the first reported case of isocyanate-induced occupational asthma in a patient who developed symptoms of peanut allergy later in his life. However, further detailed studies are necessary to elucidate the questions posed in this report, in order to take further suitable precautions.

Abbreviations

CD: 

cluster of differention

DMI: 

diphenyl-methane di-isocyanate

FEV1: 

forced expiratory flow at first second

FVC: 

functional vital capacity

Ig: 

immunoglobulin

IFN: 

interferon

IL: 

interleukin

MMP: 

metalloproteinase

PEF: 

peak expiratory flow

TDI: 

toluene di-isiocyanate

TH: 

lymphocytes T helper.

Declarations

Acknowledgements

Written consent was obtained from a relative of patient for publication of this case report.

Authors’ Affiliations

(1)
Dept. of Allergology & Clinical Immunology, "Mother Theresa" School of Medicine
(2)
Cabinet of Allergology, District's Policlinic
(3)
Cabinet of Allergology, Policlinic of Specialties No 3
(4)
Cabinet of Allergology, Vlora Regional Hospital

References

  1. Gannon PF, Berg AS, Gayosso R, Henderson B, Sax SE, Willems HM: Occupational asthma prevention and managements in industry – an example of a global programme. Occup Medicine 2005, 55: 600–5. 10.1093/occmed/kqi184View ArticleGoogle Scholar
  2. Johnson VJ, Matheson JM, Luster MI: Animal models for diisocyanate asthma: answers for lingering questions. Curr Opin Allergy Clin Immunology 2004, 4: 105–10. 10.1097/00130832-200404000-00006View ArticleGoogle Scholar
  3. Tarlo SM, Liss GM: Diisocyanate-induced asthma: diagnosis, prognosis, and effects of medical surveillance measures. Appl Occup Environ Hygiene 2002, 17: 902–8. 10.1080/10473220290107101View ArticleGoogle Scholar
  4. Matheson JM, Johnson VJ, Luster MI: Immune mediators in a murine model for occupational asthma: studies with toluene diisocyanate. Toxicol Sciences 2005, 84: 99–109. 10.1093/toxsci/kfi051View ArticleGoogle Scholar
  5. Darcey D, Lipscomb HJ, Epling C, Pate W, Cherry LP, Bernstein J: Clinical findings for residents near a polyurethane foam manufacturing plant. Arch Environ Health 2002, 57: 239–46.PubMedView ArticleGoogle Scholar
  6. Kouadio K, Zheng KC, Tuekpe MK, Todoriki H, Ariizumi M: Airway inflammatory and immunological events in a rat model exposed to toluene diisocyanate. Food Chem Toxicology 2005, 43: 1281–8. 10.1016/j.fct.2005.03.005View ArticleGoogle Scholar
  7. Herrick CA, Xu L, Wisnewski AV, Das J, Redlich CA, Bottomly K: A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. J Allergy Clin Immunology 2002, 109: 873–8. 10.1067/mai.2002.123533View ArticleGoogle Scholar
  8. Herrick CA, Das J, Xu L, Wisnewski AV, Redlich CA, Bottomly K: Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation. J Allergy Clin Immunology 2003, 111: 1087–94. 10.1067/mai.2003.1413View ArticleGoogle Scholar
  9. Redlich CA, Wisniewski AV, Gordon T: Mouse models of diisocyanate asthma. Am J Respir Cell Mol Biol 2002,27(4):385–390.PubMedView ArticleGoogle Scholar
  10. Wisniewski AV, Stowe MH, Cartier A, Liu Q, Liu J, Chen L, Redlich CA: Isocyanate vapor-induced antigenicity of human albumin. J Allergy Clin Immunology 2004, 113: 1178–84. 10.1016/j.jaci.2004.03.009View ArticleGoogle Scholar
  11. Park HS, Lee SK, Kim HY, Nahm DH, Kim SS: Specific immunoglobulin E and immunoglobulin G antibodies to toluene diisocyanate-human serum albumin conjugate: useful markers for predicting long-term prognosis in toluene diisocyanate-induced asthma. Clin Exp Allergy 2002, 32: 551–5. 10.1046/j.0954-7894.2002.01349.xPubMedView ArticleGoogle Scholar
  12. Padoan M, Pozzato V, Simoni M, Zedda L, Milan G, Bononi I, Piola C, Maestrelli P, Boeschetto P, Mapp CE: Long-term follow-up of toluene diisocyanate-induced asthma. Eur Respir J 2003, 21: 637–40. 10.1183/09031936.03.00060703PubMedView ArticleGoogle Scholar
  13. Rattray NJ, Botham PA, Hext PM, Woodcock DR, Fielding I, Dearman RJ, Kimber I: Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs: influence of route of exposure. Toxicology 1994, 88: 15–30. 10.1016/0300-483X(94)90108-2PubMedView ArticleGoogle Scholar
  14. Petsonk EL, Wang ML, Lewis DM, Siegel PD, Husberg BJ: Asthma-like symptoms in wood product plant workers exposed to methylene diphenyl diisocyanate. Chest 2000, 118: 1183–93. 10.1378/chest.118.4.1183PubMedView ArticleGoogle Scholar
  15. Liu Y, Sparer J, Woskie SR, Cullen MR, Chung JS, Holm CT, Redlich CA: Qualitative assessment of isocyanate skin exposure in auto body shops: a pilot study. Am J Ind Medicine 2000, 37: 265–74. Publisher Full Text 10.1002/(SICI)1097-0274(200003)37:3<265::AID-AJIM4>3.0.CO;2-OView ArticleGoogle Scholar
  16. Sparer J, Stowe MH, Bello D, Liu Y, Gore RJ, Youngs F, Cullen MR, Redlich CA, Woskie SR: Isocyanate Exposures in Autobody Shop Work: The SPRAY Study. J Occupational Environ Hygiene 2004, 1: 570–81. 10.1080/15459620490485909View ArticleGoogle Scholar
  17. Sicherer SH, Furlong TJ, Munoz-Furlong A, Burks AW, Sampson HA: A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants. J Allergy Clin Immunology 2001, 108: 128–32. 10.1067/mai.2001.115755View ArticleGoogle Scholar
  18. Zissu D, Binet S, Limasset JC: Cutaneous sensitization to some polyisocyanate prepolymers in guinea pigs. Contact Dermatitis 1998, 39: 248–51. 10.1111/j.1600-0536.1998.tb05918.xPubMedView ArticleGoogle Scholar
  19. Gervais P, Rosenberg N, Chabaux C: The initiating role of several respiratory and skin contaminants in food allergies. Allerg Immunol (Paris) 1987,19(1):7–11.Google Scholar
  20. Rosenberg N, Gervais P: An underestimated prevalence: the association food allergy – occupational asthma. Presse Med 1986,15(34):1712–1714.PubMedGoogle Scholar
  21. Mraz J, Simek P, Chvalova D, Nohova H, Smigolova P: Studies on the methyl isocyanate adducts with globin. Chem Biol Interact 2004, 148: 1–10. 10.1016/j.cbi.2003.06.003PubMedView ArticleGoogle Scholar

Copyright

© Mingomataj et al; licensee BioMed Central Ltd. 2008

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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