- Case report
- Open Access
Multiple subcutaneous granulomas and severe rhinitis after intradermal deposition of epoxy: a case report
© The Author(s). 2016
- Received: 22 February 2016
- Accepted: 13 June 2016
- Published: 23 June 2016
We present an unusual case of subcutaneous granulomas that also highlights the importance of assessing possible associations between exposure and symptoms early in the diagnostic approach to prevent further adverse health effects. Granulomas of the skin are seen in association with several diseases and after foreign body penetration of soft tissue, but have not been described after contact with epoxy. Epoxy resins are commonly used in paints and other protective coatings, including flooring materials.
We report a case of granulomatous inflammation in a 58-year-old man after accidental intradermal deposition of unhardened epoxy. Multiple subcutaneous nodules were present on his right forearm, from hand to elbow, for a period of 6 months after the incident. Biopsies and histological analysis showed a granulomatous inflammation without necrosis. Microscopic analysis of the biopsies did not show mycobacterium tuberculosis, other bacteria, or fungal elements. Standard patch testing was negative. The nodules disappeared gradually, but intense pruritus remained. The patient returned to exposure and developed severe work related rhinitis.
This case report describes an unusual case of multiple subcutaneous granulomas after a small injury with an epoxy-contaminated tool. Initially no association between the granulomas and exposure was established and the patient returned to work and epoxy exposure. He subsequently developed severe work related rhinitis. The case highlights the challenges of establishing an association between exposure and dermal reactions and that exposure should be reduced or avoided when sensitisation to allergens may have occurred.
Granulomas of the skin are seen in association with several diseases and after foreign body penetration of soft tissue, but have not been described following contact with epoxy. The granulomatous response is chronic inflammation characterized by focal collections of macrophages, epithelioid cells, and multinucleated giant cells, and may be accompanied by necrosis and fibrosis . Granuloma formation is usually regarded as a means of defending the host from persistent exogenous or endogenous irritants that cannot be eliminated. Several diseases are characterized by the formation of granulomas, including rheumatoid arthritis, sarcoidosis, and leprosy . Infections can result in the formation of granulomas, as in tuberculosis, schistosomiasis, histoplasmosis, and cryptococcosis. Granulomas are also associated with vasculitis  and can be found when a foreign body (such as glass, wood, or metal) penetrates the soft tissues of the body . In 2012, a subset of severe asthma with granulomatous pathology was described for the first time .
Epoxy has a wide range of industrial applications, including metal coatings, use in electronic and electrical components, high-tension electrical insulators, fiber-reinforcing materials, and structural adhesives. Epoxy resins, also known as polyepoxides, are reactive prepolymers and polymers containing epoxide groups. Epoxy resins may self-react through catalytic homopolymerization, or combine with a wide range of coreactants including polyfunctional amines, acids, phenols, alcohols, and thiols. These coreactants are often referred to as hardeners or curatives. Reactions of polyepoxides with themselves or with polyfunctional hardeners form polymers that may have strong mechanical properties as well as high temperature and chemical resistance, and are thus widely used. The epoxy resin itself may be formed by a reaction between the substances bisphenol A diglycidyl and epichlorohydrin; these account for about 75 % of the epoxy resins used worldwide. Depending on the producer, the coreactants vary. Polyepoxides as highly reactive substances are known to be associated with work-related allergic contact dermatitis and occupational asthma . A possible association between rhinitis and exposure to epoxy has been reported but is not well described in the literature . We present an unusual case of subcutaneous granulomas that also highlights the importance of assessing possible associations between exposure and symptoms early in the diagnostic approach to prevent the development of further adverse health effects.
A 58-year-old man presented with multiple lesions of the skin on his right forearm from the hand to the elbow. His medical history did not include any diseases associated with granulomatous inflammation or immunosuppression, and there was no family history of granulomatous disease. Prior to the patient’s current work, he had worked with epoxy resins for 4 years, repairing concrete constructions, in the period from 1988 to 1992. He had no exposure to epoxy in the period from 1992 to 1998 and had since then worked for 15 years as an industrial flooring specialist constructing epoxy floors. He had daily contact with polyepoxides, which he first would use as a coating on concrete floors. After hardening, he would use a primer over the first layer and add a final layer of epoxy compound. The patient blended the compounds together directly before he applied the mixture to the floor with a mason’s trowel. He reported sporadic use of gloves and a filter mask while working with epoxy compounds.
Epoxy resins can cause both immediate and delayed allergic reactions, but immediate reactions are rare [8–10]. It is known also that components associated with epoxy resins such as acid anhydrides have potent direct irritant effects on the skin  and thus may induce irritant dermatitis. Our patient developed granulomas in a large area around the wound, thus embolization of material from the contaminated tool may be considered as a possible mechanism of the granulomas. Displacement of bisphenol A polycarbonate, a polymer commonly used in biomedical devices such as indwelling catheters and granulomas of the lung , has been described in one case report. It is also known that indwelling biomedical devices can disintegrate and embolize into lymphatic vessels. As an example, foreign body granulomas may occur locally after injection of silicone in cosmetic procedures .
In the present case, allergy to epoxy was suspected and standard patch testing performed. However, no allergy against epoxy was revealed and the patient returned to his workplace. His IgE level increased between two visits in our department. This may indicate an allergic response, but could not be directly attributed to the epoxy exposure because we had no evidence of a specific allergic reaction. Most commonly, epoxy exposures will result in irritant or allergic contact dermatitis that will not result in elevations of total IgE. Exposure to low molecule weight chemicals such as epoxy can, however, result in mixed immunological responses which may be IgE-mediated .
It is known that testing for epoxy allergy can be challenging and that epicutan tests may give false-negative results, thus testing with workplace substances is recommended [7, 13]. Unfortunately, our patient was not referred to the department of occupational and environmental medicine before he returned to work and continued his epoxy exposure. When further approaches were made to establish an association between exposure and his dermal reactions, he had already developed severe rhinitis. The patient then did not want to perform specific challenge testing because he feared worsening of symptoms. In Norway, patch tests with workplace substances can be performed in hospitals with a department of dermatology, nonetheless SiC-testing is limited to one specialist center only. Because attention has been drawn to possible adverse effects from the lower respiratory tract induced by SiC-testing , this limits the use of such testing further. In our case, the assessment of work relation thus had to rely on specialist assessment alone. Although questions that identify rhinitis symptoms at work, which improve on days away from work, may have a high sensitivity for detecting occupational disease, the specificity may be relatively low as shown for work-related asthma . Thus, it is important to stress that exposure is reduced or avoided until assessment of possible work relation has been made.
Since specific IgE was not examined, and taking the limitations of the skin prick test into consideration, it is possible also that that the patient’s rhinitis was caused by another work related exposure. His work as an industrial flooring specialist may have involved mixed and multiple chemical exposures. For our patient, early recognition of an association between the dermal reactions and exposure probably could have secured the use of personal protective equipment or other means to stop or reduce exposure. Instead, the worker returned to exposure and developed severe work related upper airway symptoms. It is difficult to know if avoidance of exposure at an earlier stage could have prevented the development of respiratory symptoms for this worker. However, after the establishment of the diagnosis, the patient avoided further exposure to epoxy products and reported improvement of symptoms from the nose.
We report an unusual case of multiple subcutaneous granulomas and severe work related rhinitis after a small injury with an epoxy-contaminated tool. It remains unclear whether the development of rhinitis in our patient may be a result of sensitization after intradermal deposition of epoxy or other irritants, or represents a delayed response to long-term airborne occupational exposure. However, the case highlights the challenges of establishing the association between exposure and dermal reactions. It may also be a reminder of the potential major role for the skin in respiratory allergy and that efforts should be made to prevent sensitization through skin exposure.
CRP, C-reactive protein; IgE, immunoglobulin-E; SiC, specific inhalation challenge test
Financial support for writing the manuscript was provided by Telemark Hospital, Skien, Norway.
SR examined the patient in the outpatient clinic at the Department of Environmental and Occupational Medicine, Telemark Hospital and was the first author of the manuscript. AKMF supervised the patient care and revised the manuscript. Both authors have approved the final version of the manuscript.
SR: MD and specialist in occupational and environmental medicine. AKMF: MD, PhD, specialist in occupational and environmental medicine.
The authors declare that they have no competing interests.
Ethics approval and consent to participate
Written informed consent was obtained from the patient for publication of the case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Ethical clearance is not required from the Norwegian Regional Committee for Medical and Health Research Ethics for case reports with initial intention to treat and not for research.
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