Table 2 Clinical and cytology characteristics of silicosis patients and healthy volunteers
Characteristics | Overall | Samples for detection of Nrf2-related molecular | Samples for RNA sequencing | |||
|---|---|---|---|---|---|---|
Healthy Controls(n = 62) | Silicosis Patients(n = 77) | Healthy Controls(n = 36) | Silicosis Patients(n = 36) | Healthy Controls(n = 3) | Silicosis Patients(n = 3) | |
Age (years) | 52.56 ± 6.18 | 51.55 ± 8.38 | 52.19 ± 6.49 | 54.31 ± 7.50 | 52.67 ± 9.07 | 53.67 ± 9.29 |
BMI (kg/m2) | 25.01 ± 3.36 | 25.47 ± 3.15 | 25.43 ± 3.34 | 25.62 ± 2.78 | 22.79 ± 2.66 | 27.25 ± 2.93 |
Smokers/non-Smokers | 32/45 | 28/38 | 16/20 | 15/21 | 0/3 | 0/3 |
SBP (mmHg) | 126.13 ± 15.38 | 130.00 ± 14.60 | 123.47 ± 14.63 | 128.19 ± 9.19 | 130.00 ± 10.00 | 125.00 ± 5.00 |
DBP (mmHg) | 84.84 ± 9.19 | 85.00 ± 9.42 | 84.03 ± 8.77 | 82.64 ± 6.38 | 85.00 ± 5.00 | 76.67 ± 5.77 |
Percentage of FVC (%) | 91.05 ± 9.24 | 80.81 ± 23.54# | 93.19 ± 6.68 | 79.97 ± 18.97# | 89.33 ± 4.04 | 66.63 ± 7.51# |
Percentage of FEV1.0 (%) | 94.05 ± 7.67 | 84.35 ± 19.68# | 90.72 ± 8.70 | 76.18 ± 23.59# | 91.33 ± 5.51 | 67.07 ± 9.64* |
WBC (×106/L) | 5.90 ± 1.35 | 6.04 ± 1.28 | 5.88 ± 1.37 | 5.85 ± 1.27 | 5.70 ± 1.05 | 6.59 ± 0.92 |
Neutrophils (× 106/L) | 3.70 ± 1.02 | 3.40 ± 1.16 | 3.51 ± 0.72 | 3.26 ± 0.87 | 3.77 ± 0.93 | 3.67 ± 0.79 |
Monocytes (×106/L) | 0.23 ± 0.09 | 0.47 ± 0.15# | 0.23 ± 0.08 | 0.40 ± 0.10# | 0.20 ± 0.10 | 0.38 ± 0.16* |
Lymphocytes (×106/L) | 2.07 ± 0.65 | 2.03 ± 0.65 | 1.97 ± 0.63 | 1.99 ± 0.75 | 1.73 ± 0.32 | 2.06 ± 0.67 |
TGF-β(pg/mL) | 31.26 ± 3.23 | 44.58 ± 3.42# | 28.85 ± 3.22 | 47.59 ± 4.98* | 25.20 ± 7.56 | 62.54 ± 4.89# |