IFEN: Report on pesticides in waters: Data 2003–2004. Volume 5. Institut Français de l'Environnement, Orléans, France; 2006:15–20.
Google Scholar
Takahashi M, Horie M, Aoba N: Analysis of glyphosate and its metabolite, aminomethylphosphonic acid, in agricultural products by HPLC. Shokuhin Eiseigaku Zasshi 2001, 42: 304–308. 10.3358/shokueishi.42.304
Article
CAS
PubMed
Google Scholar
Spiroux de Vendômois J, Roullier F, Cellier D, Séralini GE: A comparison of the effects of three GM corn varieties on mammalian health. Int. J. Biol. Sci 2009, 5: 706–726.
Article
Google Scholar
Williams GM, Kroes R, Munro IC: Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for human. Regul. Toxicol. Pharmacol 2000, 31: 117–165. 10.1006/rtph.1999.1371
Article
CAS
PubMed
Google Scholar
Richard S, Moslemi S, Sipahutar H, Benachour N, Séralini GE: Differential effects of glyphosate and Roundup on human placental cells and aromatase. Environ. Health Perspec 2005, 113: 716–720. 10.1289/ehp.7728
Article
CAS
Google Scholar
Benachour N, Moslemi S, Sipahutar H, Séralini GE: Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination. Toxicol. Appl. Pharmacol 2007, 222: 129–140. 10.1016/j.taap.2007.03.033
Article
CAS
PubMed
Google Scholar
Benachour N, Séralini GE: Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem. Res. Toxicol 2009, 22: 97–105. 10.1021/tx800218n
Article
CAS
PubMed
Google Scholar
Gasnier C, Dumont C, Benachour N, Clair E, Chagnon MC, Séralini GE: Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicol 2009, 262: 184–191. 10.1016/j.tox.2009.06.006
Article
CAS
Google Scholar
Gasnier C, Benachour N, Clair E, Travert C, Langlois F, Laurant C, Decroix-Laporte C, Séralini GE: Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines. J. Occup. Med. Toxicol 2010, 5: 29–41. 10.1186/1745-6673-5-29
Article
PubMed Central
PubMed
Google Scholar
Benachour N, Sipahutar H, Moslemi S, Gasnier C, Travert C, Séralini GE: Time- and Dose-dependent effects of Roundup on human embryonic and placental cells. Environ. Contam. Toxicol 2007, 53: 126–133. 10.1007/s00244-006-0154-8
Article
CAS
Google Scholar
Urani C, Doldi M, Crippa S, Camatini M: Human-derived cell lines to study xenobiotic metabolism. Chemosphere 1998, 37: 2785–2795. 10.1016/S0045-6535(98)00321-X
Article
CAS
PubMed
Google Scholar
Knasmüller S, Mersh-Sundermann V, Kevekordes S, Darroudi F, Huber WW, Hoelzl C, Bichler J, Majer BJ: Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 2004, 198: 315–328.
Article
PubMed
Google Scholar
Westerink WM, Schoonen WG: Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells. Toxicol. In Vitro 2007, 21: 1581–1591. 10.1016/j.tiv.2007.05.014
Article
CAS
PubMed
Google Scholar
Bu-Abbas A, Clifford MN, Walker R, Ioannides C: Contribution of caffeine and flavanols in the induction of hepatic phase II activities by green tea. Food Chem. Toxicol 1998, 36: 617–621. 10.1016/S0278-6915(98)00019-2
Article
CAS
PubMed
Google Scholar
Gebhardt R: Antioxydative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Drug Res 2003, 12: 823–830.
Google Scholar
Hikino H, Kiso Y, Wagner H, Fiebig M: Antihepatotoxic actions of flavonolignans from Silybum marianum fruits. Planta Medica 1984, 50: 248–250. 10.1055/s-2007-969690
Article
CAS
PubMed
Google Scholar
Lieber CS, Leo MA, Ren C, DeCarli LM: Silymarin retards the progression of alcohol-induced hepatic fibrosis in baboons. J. Clin. Gastroenterol 2003, 37: 336–339. 10.1097/00004836-200310000-00013
Article
CAS
PubMed
Google Scholar
Li RZ, Pei HP, Ji XJ: Antimutagenic activity and metabolic transformation of ranunculin by rat liver microsomes. Yao Xue Xue Bao 1993, 28: 481–485.
CAS
PubMed
Google Scholar
Pavlica S, Gebhardt R: Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells. Free Radic. Res 2005, 39: 1377–1390. 10.1080/09670260500197660
Article
CAS
PubMed
Google Scholar
Banno N, Akihisa T, Tokuda H, Yasukawa K, Higashihara H, Ukiya M, Watanabe K, Kimura Y, Hasagawa J, Nishino H: Triterpene acids from the leaves of Perilla fructescens and their anti-inflammatory and antitumor-promoting effects. Biosci. Biotechnol. Biochem 2004, 68: 85–90. 10.1271/bbb.68.85
Article
CAS
PubMed
Google Scholar
Tunon H, Olavsdotter C, Bohlin L: Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. J. Ethnopharmacol 1995, 48: 61–76. 10.1016/0378-8741(95)01285-L
Article
CAS
PubMed
Google Scholar
Apati P, Szentmihalyi K, Kristo ST, Papp I, Vinkler P, Szoke E, Kery A: Herbal remedies of Solidago correlation of phytochemical characteristics and antioxydative properties. J. Pharm. Biomed. Anal 2003, 32: 1045–1053. 10.1016/S0731-7085(03)00207-3
Article
CAS
PubMed
Google Scholar
Thiem B, Goslinska O: Antimicrobial activity of Solidago virgaurea L. from in vitro cultures. Fitoterapia 2002, 73: 514–516. 10.1016/S0367-326X(02)00180-6
Article
PubMed
Google Scholar
Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S, Fujiwara H: Inhibition of activator protein 1 activity by berberine in human hepatoma cells. Planta Medica 1999, 65: 381–383. 10.1055/s-2006-960795
Article
CAS
PubMed
Google Scholar
Janbaz KH, Gilani AH: Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000, 71: 25–33. 10.1016/S0367-326X(99)00098-2
Article
CAS
PubMed
Google Scholar
Lin SC, Chung TC, Lin CC, Ueng TH, Lin YH, Lin SY, Wang LY: Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Am. J. Chi. Med 2000, 28: 163–173. 10.1142/S0192415X00000210
Article
CAS
Google Scholar
Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen IC, Wang LY: Hepatoprotective effects of Arctium lappa Linne on liver injuries induced by chronic ethanol consumption and potentiated by carbon tetrachloride. J. Biomed. Sci 2002, 9: 401–409.
PubMed
Google Scholar
Trojanova I, Rada V, Kokoska L, Vlkova E: The bifidogenic effect of Taraxacum officinale root. Fitoterapia 2004, 75: 760–763. 10.1016/j.fitote.2004.09.010
Article
CAS
PubMed
Google Scholar
Seo SW, Koo HN, An HJ, Kwon KB, Lim BC, Seo EA, Ryu DG, Moon G, Kim HY, Kim HM, Hong SH: Taraxacum officinale protects against cholecystokinin-induced acute pancreatitis in rat. World J. Gastroenterol 2005, 11: 597–599.
Article
PubMed Central
PubMed
Google Scholar
Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth 1983, 65: 55–63. 10.1016/0022-1759(83)90303-4
Article
CAS
Google Scholar
Denizot F, Lang R: Rapid colorimetric assay for cell growth and survival Modification to the tetrazolium dye procedure giving improved sensitivity and reliability. J. Immunol. Meth 1986, 89: 271–277. 10.1016/0022-1759(86)90368-6
Article
CAS
Google Scholar
Auvray P, Sourdaine P, Moslemi S, Séralini GE, Sonnet P, Enguehard C, Guillon J, Dallemagne P, Bureau R, Rault S: MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase. J. Ster. Biochem. Mol. Bio 1999>, 70: 59–71.
Article
CAS
Google Scholar
Habig WH, Pabst MJ, Jacoby WB: Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol Chem 1974, 249: 7130–7139.
CAS
PubMed
Google Scholar
U.S EPA: Environmental Protection Agency: Glyphosate; notice of filing a pesticide petition to establish a tolerance for a certain pesticide chemical in or on food. Fedral Register Environment Documents 2006.
Google Scholar
Galloway T, Cipelli R, Guralnick J, Ferrucci L, Bandinelli S, Corsi AM: Daily Bisphenol A Excretion and Associations with Sex Hormone Concentrations: Results from the InCHIANTI Adult Population Study. Environ Health Perspect 2010.
Google Scholar
Curwin BD, Hein MJ, Barr DB, Striley C: Comparison of immunoassay and HPLC-MS/MS used to measure urinary metabolites of atrazine, metolachlor, and chlorpyrifos from farmers and non-farmers in Iowa. J Expo Sci Environ Epidemiol 2010, 20: 205–12. 10.1038/jes.2009.15
Article
CAS
PubMed
Google Scholar
Bisphenol A: Toxic Plastics Chemical in Canned Food[http://www.ewg.org/reports/bisphenola]
Izzotti A, Kanitz S, D'Agostini F, Camoirano A, De Flora S: Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice. Mutat Res 2009, 679: 28–32.
Article
CAS
PubMed
Google Scholar
Casas E, Bonilla E, Ducolomb Y, Betancourt M: Differential effects of herbicides atrazine and fenoxaprop-ethyl, and insecticides diazinon and malathion, on viability and maturation of porcine oocytes in vitro. Toxicol In Vitro 2010, 24: 224–30. 10.1016/j.tiv.2009.09.004
Article
CAS
PubMed
Google Scholar
Holloway AC, Anger DA, Crankshaw DJ, Wu M, Foster WG: Atrazine-induced changes in aromatase activity in estrogen sensitive target tissues. J Appl Toxicol 2008, 28: 260–70. 10.1002/jat.1275
Article
CAS
PubMed
Google Scholar
Schoonen WG, de Roos JA, Westerink WM, Débiton E: Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents. Toxicol In Vitro 2005, 19: 491–503. 10.1016/j.tiv.2005.01.002
Article
CAS
PubMed
Google Scholar
Jondeau A, Dahbi L, Bani-Estivals MH, Chagnon MC: Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants. Toxicology 2006, 226: 218–228. 10.1016/j.tox.2006.07.007
Article
CAS
PubMed
Google Scholar
Janbaz KH, Saeed SA, Gilani AH: Protective effect og rutin on paracetamol- and CCl4-induced hepatotoxicity in rodents. Fitoterapia 2002, 73: 557–563. 10.1016/S0367-326X(02)00217-4
Article
CAS
PubMed
Google Scholar
Ovesna Z, Kozics K, Slamenova D: Protective effects of ursolic acid and oleanolic acid in meukemic cells. Mutat. Res 2006, 600: 131–137.
Article
CAS
PubMed
Google Scholar
Mitra S, Gole M, Samadjar K, Sur RK, Chakraborty BN: Antihepatotocix activity of Chelidonium majus . Int. J. Pharmacognosy 1992, 30: 125–128. 10.3109/13880209209053974
Article
Google Scholar
Biswas SJ, Bhattacharjee N, Khuda-Bukhsh AR: Efficacy of a plant extract (Chelidonium majus L.) in combating induced hepatocarcinogenesis in mice. Food Chem. Toxicol 2007, 46: 1474–1487.
Article
PubMed
Google Scholar
McDanell R, McLean AEM: Chemical and biological properties of indole glucosinolates (glucobrassicins): A review. Food Chem. Toxicol 1987, 26: 59–70.
Article
Google Scholar
Wiebel FJ, Lambiotte M, Singh J, Summer KH, Wolff T: Expression of carcinogen-metabolizing enzymes in continuous cultures of mammalian cells. Biochemicals Basis of Chemical Carcinogenesis, Raven Press, New York; 1984:77–88.
Google Scholar
Knasmüller S, Parzefall W, Sanyal R, Ecker S, Schwab C, Uhl M, Mersh-Sundermann V, Williamson G, Hietsch G, Langer T, Darroudi F, Natarajan AT: Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens. Mut. Res 1998, 402: 185–202.
Article
Google Scholar
Niwa T, Fujimoto M, Kishimoto K, Yabusaki Y, Ishibashi F, Katagiri M: Metabolism and interaction of bisphenol A in human hepatic cytochrome P450 and steroidogenic CYP17. Biol Pharm Bull 2001, 24: 1064–1067. 10.1248/bpb.24.1064
Article
CAS
PubMed
Google Scholar
Niwa T, Maekawa Y, Fujimoto M, Kishimoto K, Yabusaki Y, Ishibashi F, Katagiri M: Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol. Biol Pharm Bull 2002, 25: 235–238. 10.1248/bpb.25.235
Article
CAS
PubMed
Google Scholar